Original researches
Cluster mast cell interactions in chronic endometritis in women with recurrent pregnancy loss
Abstract
Chronic endometritis (CE) remains one of the most common causes of endometrial implantation failure. The morphological determinants of recurrent miscarriage (RM) include alterations in the local immune landscape, with the integration of mast cells (MCs) into the endometrium.
Morphological changes in the placenta in case of antenatal death of a full-term fetus
Abstract
Background. The placenta plays a key role in fetal development, and its study is crucial for understanding the causes of adverse perinatal outcomes. However, pathological changes in the placenta often remain undetected until the fetus dies. Therefore, the relationship
Genetic markers of missed miscarriage in obesity
Abstract
Obesity is a chronic, multifactorial, non-communicable condition that affects many organs and systems, including the reproductive system. In 2022, the World Health Organization estimated that overweight and obesity affected 2.5 billion adults (43% men and 44% women). Obesity
Diagnostic value of combined MRI features and biochemical markers in predicting the degree of placental accreta
Abstract
The increasing incidence of placenta accreta spectrum (PAS) determines the need to search for reliable predictors of clinical outcomes. Of particular interest is the combined use of magnetic resonance imaging (MRI) and biochemical markers to predict the degree of invasion
Perinatal outcomes of late premature spontaneous labor
Abstract
Background. Late preterm spontaneous labor (LPSL) between 34 0 and 36 6 weeks accounts for up to 75% of all preterm births and are associated with a risk of neonatal complications. Despite the clinical proximity to full-term birth, the functional immaturity of newborns
Pelvic organ prolapse and extragenital diseases
Abstract
Pelvic organ prolapse (POP) is a significant medical and social problem affecting up to 50% of postmenopausal women. The pathogenesis of POP is traditionally attributed to mechanical factors, while the role of cardiometabolic disorders remains poorly understood. The aim of
Pelvic floor muscle strength in women with pelvic organ prolapse
Abstract
Pelvic organ prolapse (POP) is a common condition that significantly reduces women’s quality of life. Despite extensive research into the mechanisms of POP, the role of pelvic floor muscle (PFM) function and the influence of their strength on the development and
The effectiveness of two-stage surgical treatment of pelvic organ prolapse in reproductive age
Abstract
Background. Pelvic organ prolapse is a widespread and clinically significant problem in gynecology, especially in patients of late reproductive age. The aim is to evaluate the effectiveness of the performed surgical treatment – laparoscopic lateral fixation of the
Quality of life assessment in postmenopausal patients with vulvar lichen sclerosus
Abstract
The aim of the study was to assess the quality of life of postmenopausal patients with vulvar lichen sclerosus (VLS). Material and methods. This prospective study included forty-five 39–79-year-old women with VLS. After assessing the disease using Günthert
Obstetric and perinatal outcomes in gestational urosepsis
Abstract
Background. Urinary tract infections are one of the most common complications during pregnancy and can cause maternal and perinatal morbidity, and in some cases, mortality. Gestational urosepsis is a potentially fatal condition requiring immediate medical intervention.
Effectiveness and safety of D-chiro-inositol in combination therapy of endometrial hyperplasia without atypia: results of a randomized placebo-controlled study
Abstract
The aim of the study was to evaluate the efficacy and safety of D-chiro-inositol as part of combination therapy for endometrial hyperplasia without atypia. Material and methods. A prospective, randomized, double-blind, placebo-controlled study was conducted in 60 patients
Predicting prematurity of pregnancy in obesity
Abstract
The aim of the study – to identify the immune determinants of placental dysfunction as prognostic risk factors for preterm birth, namely: to assess the level of cytokines, humoral immunity factors and vitamin 25(OH) D in early pregnancy in obese women. Material
Polycystic ovary syndrome: from biomarker to diagnostic criterion
Abstract
Background. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, with a prevalence of 8–13%. PCOS remains undiagnosed in 70% of patients, highlighting the need for new diagnostic approaches. The 2023 International
Contraversations in assessment tools for missed abortion
Abstract
Background. Diagnosis of missed abortion (MA) in the absence of signs of embryo viability in some cases causes difficulties. As an additional method for diagnosing MA, evaluation of placental hormones in the maternal bloodstream is often used. The aim of the study was to
Reviews
Endometriosis and recurrent implantation failure: the modern paradigm
Abstract
The aim of the study was to systematize current understanding of the molecular mechanisms underlying recurrent implantation failure (RIF) in endometriosis, as well as evidence-based diagnostic and therapeutic approaches to patient management, including prognosis and
A modern view on the pathogenesis of late reproductive loss
Abstract
Late spontaneous miscarriages remain a significant problem in obstetric practice and reproductive medicine, significantly impacting the physical and psychological health of women. Despite advances in prenatal diagnosis and pregnancy management, the causes of late
Risk factors for the development of borderline ovarian tumors tumors
Abstract
The development of borderline ovarian tumors (BOTs) in women before they have completed their reproductive plans (average age 38) justifies the advantage of organ-preserving surgery in the treatment of BOTs for preserving fertility. However, such surgeries are associated
CLINICAL OBSERVATIONS
Pregnancy by in vitro fertilization after surgical treatment of diffuse adenomyosis using the H. Osada method (clinical case)
Abstract
Women suffering from adenomyosis often want not only to preserve the uterus, but also to realize their reproductive function in the future. Adenomyomectomy with the restoration of the uterine wall in a three-flap method using the Hisao Osada technique is a promising
International recommendations
Congenital anomalies after first-trimester dydrogesterone therapy during in vitro fertilization
Abstract
Background. Congenital anomalies are a critical public health concern and warrant prioritization in research. However, the teratogenic potential of dydrogesterone (DYG) remains uncertain and a subject of ongoing debate. Methods. This retrospective cohort study included
Announcements