Neuropeptides in regulation of the female reproductive system functions

• Anna N. Lysova
• Marina B. Khamoshina
• Elena G. Zarubina

Abstract

This article is a review of modern literature, which reflects data on new views on the mechanisms of regulation of the hypothalamic-pituitary-ovarian axis and on the role of neuropeptides in this process, which are currently recognized as the highest level of regulation of the female reproductive system. The article offers a review of the literature and a description of the work of KNDy neurons and the features of the effect of the neuropeptides synthesized by them on the work of the reproductive system of women. The review discusses the characteristics of kisspeptin and its receptor, the characteristics and role of its cotransmitters (neurokinin B and dinorphin).

In addition, the review provides data on the role of the recently discovered neurohormone – gonadotropin-inhibiting hormone, which is an antagonist of kisspeptin and affects the emissions of GnRH and reproduction.

Keywords: kisspeptin; gonadotropin-inhibitory hormone; neuropeptides; neurokinin B; dinorphin

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