Features of early reproductive losses in obese women

• Ekaterina A. Kuzmina
• Sergey I. Kyrtikov
• Irina V. Bekbaeva
• Anastasiya N. Akhmatova
• Maya T. Khubetsova
• Mukhammednazar A. Soyunov
• Aylara A. Orazmuradova

Abstract

Obesity, being the main non-infectious pandemic of the 21^st century, is associated with a wide range of obstetric and perinatal complications. The problem of early pregnancy in patients with excess adipose tissue is the high frequency of early reproductive losses in the absence of genetic disorders of the embryo. The search for the causes of miscarriage in this group of patients is an urgent problem in modern obstetrics. This article discusses the main pathogenetic mechanisms of early reproductive losses in obesity.

Keywords:obesity; early reproductive losses; miscarriage; progesterone receptors; endometrium; oocytes

REFERENCES

1. Remneva O.V., Chernova A.E., Kolyado O.V., Fadeeva N.I. Medical and social risk factors for late spontaneous miscarriage // Issues of gynecology, obstetrics and perinatology. 2022; 21 (6): 73–8. DOI: https://doi.org/10.20953/1726-1678-2022-6-73-78 (in Russian)

2. Vlasova N.A., Dikareva L.V., Suverneva A.A., et al. On the question of the possibility of predicting the risk of pregnancy loss in the early stages. Astrakhan Medical Journal. 2023; 18 (2): 39–46. DOI: https://doi.org/10.29039/1992-6499-2023-2-39-46 (in Russian)

3. Samigullina A. E. Analysis of the frequency and structure of miscarriage. Modern problems of science and education. 2018; 6: 141. (in Russian)

4. V.E. Radzinsky, A.V. Solovyova, V.M. Kuleshov, et al. Possibility of improving the health of women with overweight and obesity at the stage of preconceptional preparation. Obstetrics and Gynecology. 2023; 1: 83–90. DOI: https://doi.org/10.18565/aig.2022.292 (in Russian)

5. Voronova K.V. Some immunohormonal aspects of recurrent miscarriage. Trends in the development of science and education. 2023; 93-7: 29–31. DOI: https://doi.org/10.18411/trnio-01-2023-337 (in Russian)

6. Shirai O.V., Aslanov B.I., Rishchuk S.V., et al. Epidemiological assessment of risk factors for miscarriage (scientific review). Preventive and Clinical Medicine. 2022; 4 (85): 53–63. DOI: https://doi.org/10.47843/2074-9120_2022_4_53 (in Russian)

7. Obesity and overweight, The World Health Organization (WHO), 2021.

8. World Obesity Atlas, 2023.

9. Alieva F.Kh. Features of the course of pregnancy and childbirth in patients with varying degrees of obesity. Perm Medical Journal. 2019; 36 (1): 21–6. DOI: https://doi.org/10.17116/pmj 36121-26 (in Russian)

10. Allahyarov D.Z., Petrov Yu.A., Palieva N.V. Modern aspects of preconception preparation of patients with metabolic syndrome. Chief Physician of the South of Russia. 2023; 1 (87): 29–32.EDN MJVCTZ. (in Russian)

11. Radzinsky V.E., Botasheva T.L., Papysheva O.V., et al. Obesity. Diabetes. Pregnancy. Versions and contraversions. Clinical practices. Prospects. Edit. by V.E. Radzinsky, T.L. Botasheva, G.A. Kotaish (responsible editor). Moscow: GEOTAR-Media, 2020. 528 p. DOI: https://doi.org/10.33029/9704-5442-8-OBE-2020-1-528 (in Russian)

12. Volkov V.G., Akhilgova Z.S. Risk factors for early pregnancy losses. Bulletin of new medical technologies. 2020; 1: 66–72. DOI: 10.24411/2075-4094-2020-16597 (in Russian)

13. Zhukovets I.V., Leshchenko O.Ya., Andrievskaya I.A., Petrova K.K. The role of cytokines in the development of early pregnancy losses in women with a history of metabolic disorders. Acta Biomedica Scientifica (East Siberian Biomedical Journal). 2020: 5 (4): 8–13. DOI: https://doi.org/10.29413/ABS.2020-5.4.1 (in Russian)

14. Fortygina Yu.A., Makarova N.P., Nepsha O.S., et al. The role of lipidomic studies in human reproduction and the outcomes of infertility treatment programs using assisted reproductive technologies / Obstetrics and Gynecology. 2022; 10: 14–20. DOI: https://doi.org/10.18565/aig.2022.10.14-20 (in Russian)

15. Malasevskaia I., Sultana S., Hassan A., Hafez A.A., Onal F., Ilgun H., Heindl S.E. A 21st Century Epidemy-Obesity: And Its Impact on Pregnancy Loss. Cureus. 2021; 13 (1): e12417. DOI: 10.7759/cureus.12417. PMID: 33542866. PMCID: PMC7847782.

16. Mikhalev S.A., Masalimova D.N. Obesity is a risk factor of recurrent miscarriage. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie [Obstetrics and Gynecology: News, Opinions, Training]. 2023; 11. Supplement: 105–8. DOI: https://doi.org/10.33029/2303-9698-2023-11-suppl-105-108 (in Russian)

17. Shirai O.V., Aslanov B.I., Rishchuk S.V., et al. Epidemiological assessment of risk factors for miscarriage (scientific review). Preventive and Clinical Medicine. 2022; 4 (85): 53–63. DOI https://doi.org/10.47843/2074-9120_2022_4_53 (in Russian)

18. Amiri M., Ramezani Tehrani F. Potential Adverse Effects of Female and Male Obesity on Fertility: A Narrative Review. Int J Endocrinol Metab. 2020; 18 (3): e101776. DOI: 10.5812/ijem.101776. PMID: 33257906. PMCID: PMC7695350.

19. Petrenko Yu.V., Prokopyeva N.E., Kovaleva V.V., Kovaleva V.V. Features of adiponectin in the mother-placenta-fetus system. University Therapeutic Journal. 2023. 5 (3): 41–9. DOI: https://doi.org/10.56871/UTJ.2023.42.20.004 (in Russian)

20. Palieva N.V., Tarasova A.Yu., Petrov Yu.A., Chernavsky V.V. Psychological characteristics and health status of pregnant women at risk of miscarriage and premature birth. Chief Doctor of the South of Russia. 2023; 2 (88): 34–8. EDN QSCSRP. (in Russian)

21. Rahnama R., Rafiee M., Fouladi S., Akbari-Fakhrabadi M., Mehrabian F., Rezaei A. Gene expression analysis of membrane progesterone receptors in women with recurrent spontaneous abortion: a case control study. BMC Res Notes. 2019; 12 (1): 790. DOI: 10.1186/s13104-019-4787-x. PMID: 31801604. PMCID: PMC6894300.

22. Ahmad R., Haque M. Obesity: A Doorway to a Molecular Path Leading to Infertility. Cureus. 2022; 14 (10): e30770. DOI: https://doi.org/10.7759/cureus.30770 PMID: 36320802; PMCID: PMC9612950.

23. Balci M., Özdemir G. Differential Expression of EGFR-1, MMP-3, and MMP-9 in Spontaneous Abortions, Induced Abortions, and Tubal Pregnancies. Turk Patoloji Derg. 2019; 35 (1): 1–8. DOI: https://doi.org/10.5146/tjpath.2018.01432 PMID: 30596394. (in English)

24. Karachrysafi S., Georgiou P., Kavvadas D., Papafotiou F., Isaakidou S., Grammatikakis I.E., Papamitsou T. Immunohistochemical study of MMP-2, MMP-9, EGFR and IL-8 in decidual and trophoblastic specimens of recurrent pregnancy loss cases. J Matern Fetal Neonatal Med. 2023; 36 (1): 2218523. DOI: https://doi.org/10.1080/14767058.2023.2218523 PMID: 37258409.

25. Langley-Evans S.C., Pearce J., Ellis S. Overweight, obesity and excessive weight gain in pregnancy as risk factors for adverse pregnancy outcomes: A narrative review. J Hum Nutr Diet. 2022; 35 (2): 250–64. DOI: https://doi.org/10.1111/jhn.12999 PMID: 35239212. PMCID: PMC9311414.

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