To the content
Спецвыпуск . 2024

Clinical and morphological parallels of the consistency of the uterine scar after cesarean section

Abstract

In recent years, the circle of supporters of the management of childbirth in patients with an operated uterus through the natural birth canal has been expanding. An attempt at vaginal delivery can protect a woman from complications associated with repeated surgery, but requires a comprehensive risk assessment. The existing controversies regarding the tactics of managing patients in this cohort prove that this problem has not yet been found a clear solution and there are many reasons for this: first of all, this is the fear of uterine rupture along the existing scar. In the structure of contraindications for natural childbirth after a cesarean section (СS), the main role is given to assessing the consistency of the uterine scar.

The aim of the study was to improve the criteria for selecting women for vaginal birth after cesarean section.

Material and methods. The study involved 54 patients after repeated CS, who underwent morphological and immunohistochemical examination of excised scars. Retrospectively, based on birth histories, a comparative analysis of clinical and anamnestic factors affecting scar repair was carried out.

Results. During the study it was shown that the healing of a postoperative wound on the uterus was influenced to a greater extent by: complicated course of postoperative period (chances of scar failure were 4.48 times higher), age (3.39 times higher in women aged 35 years and older), presence of extragenital diseases (4.03 times higher), urgency (a history of emergency CS increased the likelihood of the formation of an incompetent scar by 3.53 times).

Keywords:caesarean section; uterine scar; pathological examination; immunohistochemical study

Funding. The study was carried out within the framework of budget funding.

Conflict of interest. The authors declare no conflict of interest.

Сontribution. Concept and design of the study – Startseva N.M., Khamoshina M.B., Mikhaleva L.M.; collection and processing of materials – Belyaeva E.K., Markaryan N.M., Loginova E.V., Biryukov A.E.; text writing – Startseva N.M., Belyaeva E.K., Loginova E.V.; editing – Khamoshina M.B., Mikhaleva L.M.

For citation: Belyaeva E.K., Startseva N.M., Markaryan N.M., Khamoshina M.B., Loginova E.V., Mikhaleva L.M., Biryukov A.E. Clinical and morphological parallels of the consistency of the uterine scar after cesarean section. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie [Obstetrics and Gynecology: News, Opinions, Training]. 2024; 12. Supplement: 13–9. DOI: https://doi.org/10.33029/2303-9698-2024-12-suppl-13-19 (in Russian)

REFERENCES

1. Radzinsky V.E. Obstetric aggression, v. 2.0. Moscow: StatusPraesens, 2017: 872 p. (in Russian)

2. Goonewardene M., Kumara D.M.A., Arachchi D.R., Vithanage R., Wijeweera R. The rising trend in caesarean section rates: should we and can we reduce it. Sri Lanka J Obstet Gynaecol. 2012; 34: 1118. DOI: https://doi.org/10.4038/sljog.v34i1.4816

3. Martin J.A., Hamilton B.E., Osterman M.J.K., Driscoll A.K., Drake P. Births: final data for 2016. Natl Vital Stat Rep. 2018; 67 (1): 1–55. PMID: 29775434.

4. ACOG Practice Bulletin No. 205. Vaginal birth after cesarean delivery. Obstet Gynecol. 2019; 133 (2): e110–27. DOI: https://doi.org/10.1097/AOG.0000000000003078

5. Clinical recommendations «Postoperative scar on the uterus, requiring medical care for the mother during pregnancy, childbirth and the postpartum period». Moscow, 2021: 6–7. (in Russian)

6. Mudrov V.A., Mochalova M.N., Mudrov A.A. Features of delivery of pregnant women with a scar on the uterus through the natural birth canal at the present stage. Zhurnal akusherstva i zhenskikh bolezney [Journal of Obstetrics and Women’s Diseases]. 2018; 67 (1): 26–37. (in Russian)

7. Perepelova T.A., Gazazyan M.G., Bezhin A.I., Ishunina T.A. Diagnosis of the condition of the lower segment of the uterus after cesarean section. Rossiyskiy vestnik akushera-ginecologa [Russian Bulletin of Obstetrician-Gynecologist]. 2016: 16 (5): 61–6. DOI: https://doi.org/10.17116/rosakush201616561-65 (in Russian)

8. Wu Y., Kataria Y., Wang Z., Ming W.K., Ellervik C. Factors associated with successful vaginal birth after a cesarean section: a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2019; 19 (1): 360. DOI: https://doi.org/10.1186/s12884-019-2517-y

9. Markaryan N.M., Vandysheva R.A., Nizyaeva N.V., et al. Clinical and morphological assessment of scars on the uterus after cesarean section in patients with gynecological and extragenital diseases. Klinicheskaya i eksperimental’naya morfologiya [Clinical and Experimental Morphology]. 2023; 12 (1): 34–43. DOI: https://doi.org/10.31088/CEM2023.12.1.34-45 (in Russian)

10. Onoprienko N.V. Pathomorphological analysis of the consistency of myometrial scars and the use of cellular technologies to stimulate reparative processes: Diss. Novosibirsk, 2016: 428 p. (in Russian)

11. Vervoort A.J., Uittenbogaard L.B., Hehenkamp W.J., Brölmann H.A., Mol B.W., Huirne J.A. Why do niches develop in Caesarean uterine scars? Hypotheses on the aetiology of niche development. Hum Reprod. 2015; 30 (12): 2695–702. DOI: https://doi.org/10.1093/humrep/dev240 Epub 2015 Sep 25. PubMed PMID: 26409016

12. Nozhnitseva O.N., Semenov I.A., Bezhenar’ V.F. A scar on the uterus after a cesarean section and the optimal algorithm for diagnosing its condition. Luchevaya diagnostika i terapiya [Radiation Diagnostics and Therapy]. 2019; 10 (2): 85–90. DOI: http://doi.org/10.22328/2079-5343-2019-10-2-85-90 (in Russian)

13. Vuchenovich Yu.D., Novikova V.A., Radzinsky V.E., Vasil’chenko M.I., Trykina N.V., Startseva N.M., et al. Histological determinants of attempted vaginal delivery after cesarean section. Akusherstvo i ginekologiya [Obstetrics and Gynecology]. 2022; (5): 128–39. DOI: https://doi.org/10.18565/aig.2022.5.128-139 (in Russian)

14. Shchukina N.A., Buyanova S.N., Chechneva M.A., Zemskova N.Yu., Barinova I.V., Puchkova N.V., et al. The main reasons for the formation of an incompetent scar on the uterus after cesarean section. Rossiyskiy vestnik akushera-ginecologa [Russian Bulletin of Obstetrician-Gynecologist]. 2018; 18 (4): 57–61. DOI: https://doi.org/10.17116/rosakush201818457 (in Russian)

15. Krasnopol’sky V.I., Buyanova S.N., Shchukina N.A., Logutova L.S. Failure of the suture (scar) on the uterus after cesarean section: problems and solutions (editorial article). Rossiyskiy vestnik akushera-ginecologa [Russian Bulletin of Obstetrician-Gynecologist]. 2015; 15 (3): 4–8. URL: https://elibrary.ru/item.asp?id=24325065 (date of access December 19, 2022). (in Russian)

16. Bamberg C., Dudenhausen J.W., Bujak V., Rodekamp E., Brauer M., Hinkson L., et al. A prospective randomized clinical trial of single vs. double layer closure of hysterotomy at the time of cesarean delivery: the effect on uterine scar thickness. Ultraschall Med. 2018; 39 (3): 343–51. DOI: https://doi.org/10.1055/s-0042-112223

17. Stegwee S.I., Jordans I., van der Voet L.F., van de Ven P.M., Ket J., Lambalk C.B., et al. Uterine caesarean closure techniques affect ultrasound findings and maternal outcomes: a systematic review and meta-analysis. BJOG. 2018; 125 (9): 1097–108. DOI: https://doi.org/10.1111/1471-0528.15048

18. Tanos V., Toney Z.A. Uterine scar rupture – prediction, prevention, diagnosis, and management. Best Pract Res Clin Obstet Gynaecol. 2019; 59: 115–31. DOI: https://doi.org/10.1016/j.bpobgyn.2019.01.009

19. Rogov K.A., Tikhonova N.B., Boltovskaya M.N., Milovanov A.P. Morphological aspects of impaired myometrial repair after cesarean section. Klinicheskaya i eksperimental’naya morfologiya [Clinical and Experimental Morphology]. 2018; 26 (2): 48–54. DOI: https://doi.org/10.31088/2226-5988- 2018-26-2-48-54 (in Russian)

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)

CHIEF EDITORS
CHIEF EDITOR
Sukhikh Gennadii Tikhonovich
Academician of the Russian Academy of Medical Sciences, V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Moscow
CHIEF EDITOR
Kurtser Mark Arkadievich
Academician of the Russian Academy of Sciences, MD, Professor, Head of the Obstetrics and Gynecology Subdepartment of the Pediatric Department, N.I. Pirogov Russian National Scientific Research Medical University, Ministry of Health of the Russian Federation
CHIEF EDITOR
Radzinsky Viktor Evseevich
Corresponding Member of the Russian Academy of Sciences, MD, Professor, Head of the Subdepartment of Obstetrics and Gynecology with a Course of Perinatology of the Medical Department in the Russian People?s Friendship University

Journals of «GEOTAR-Media»