Prediction of congenital malformations associated with diabetes mellitus

• Eketerina V. Loginova
• Celebi G. Gagaev
• Tatevik N. Zulumyan
• Igor N. Kostin
• Marina B. Khamoshina
• Marina G. Lebedeva

Abstract

The aim of the study was to develop a model for early diagnosis and prediction of fetal congenital malformations in pregnant women with type 1 and 2 diabetes mellitus.

Material and methods. Retrospective analysis of the history of pregnancy and parameters of first ultrasound study (at 6.0–9.0 weeks) in pregnant women with and without fetal abnormalities in diabetes mellitus.

Results. Statistically significant differences between the groups were found in: fasting venous plasma glucose, glycated hemoglobin, pregravid preparation, deviations in the mean-internal diameter of the fetal bladder and the diameter of the yolk sac on the first ultrasound examination at 6.0–9.0 weeks of gestation (р<0.001). Using the discriminant analysis method, we developed a mathematical model for early (before the first screening) prediction of the probability of developing the risk of fetal abnormalities in pregnant women with diabetes mellitus with a sensitivity and specificity of 90%.

Conclusion. On the basis of the performed study, the data obtained can be used for early prediction of fetal abnormalities in pregnant women with diabetes.

Keywords:pregnancy; diabetes mellitus; congenital malformations; fetal abnormalities

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