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Спецвыпуск . 2023

Vulvar lichen sclerosus: modern approaches to diagnosis and treatment

Abstract

The problem of vulvar lichen sclerosus remains a little-studied area in gynecology. There is no single generally accepted theory of the pathogenesis of this disease, as well as a clear algorithm for treating patients. For a long time, this pathology was considered the prerogative of menopausal and postmenopausal women, but over the past decades, there has been a trend of its “rejuvenation”. At the same time, the high risk of malignancy of vulvar lichen sclerosus, which ranges from 10 to 35%, is of great concern. This review presents current data on the pathogenesis, diagnosis and treatment of vulvar lichen sclerosus, which will be useful both for obstetrician-gynecologists and for doctors of related specialties.

Keywords:vulvar lichen sclerosus; diagnosis; treatment; pathogenesis

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

For citation: Borisova A.V., Klimova O.I., Valentinova N.N. Vulvar lichen sclerosus: modern approaches to diagnosis and treatment. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie [Obstetrics and Gynecology: News, Opinions, Training]. 2023; 11. Supplement: 109–14. DOI: https://doi.org/10.33029/2303-9698-2023-11-suppl-109-114 (in Russian)

REFERENCES

1. Nair P.A. Vulvar lichen sclerosus et atrophicus. J Midlife Health. 2017; 8 (2): 55–62. DOI: 10.4103/jmh.JMH_13_17

2. Semenchak Yu.А., Snarskaya E.S. Scleroatrophic lichen. Vrach [Physician]. 2018; (8): 26–34. (in Russian)

3. Singh N., Ghatage P. Etiology, clinical features, and diagnosis of vulvar lichen sclerosus: a scoping review. Obstet Gynecol Int. 2020:748–54. DOI: 10.1155/2020/7480754

4. Semenchak Yu.A. Scleroatrophic lichen – current data on the etiology, pathogenesis, clinical features and treatment. Rossiyskiy zhurnal kozhnykh i venericheskikh bolezney [Russian Journal of Skin and Venereal Diseases]. 2019; 22 (3–4): 73–85. (in Russian)

5. Wilkinson E., Stone I. Diseases of the vulva: A clinical guide. Transl. from Engl. Moscow: BINOM, 2009: 248 p. (in Russian)

6. Kreuter A., Kryvosheyeva Y., Terras S., et al. Association of autoimmune diseases with lichen sclerosus in 532 male and female patients. Acta Derm Venereol. 2013; 93: 238–41.

7. Birenbaum D.L., Young R.C. High prevalence of thyroid disease in patients with lichen sclerosus. J Reprod Med. 2007; 52: 28–30.

8. Tran D.A., Tan X., Macri C.J., et al. Lichen Sclerosus: an autoimmunopathogenic and genomic enigma with emerging genetic and immune targets. Int J Biol Sci. 2019; 15 (7): 1429–39. DOI: 10.7150/ijbs.34613

9. Utsunomiya N., Utsunomiya A., Chino T., et al. Gene silencing of extracellular matrix protein 1 (ECM1) results in phenotypic alterations of dermal fibroblasts reminiscent of clinical features of lichen sclerosus. J. Dermatol. Sci. 2020; 100: 99–109.

10. Günthert A.R., Faber M., Knappe G. et al. Early onset vulvar lichen sclerosus in premenopausal women and oral contraceptives. Eur J Obstet Gynecol Reprod Biol. 2008;137: 56–60.

11. Marfatia Y., Surani A., Baxi R. Genital lichen sclerosus et atrophicus in females: an update. Indian J Sex Transm Dis AIDS. 2019; 40 (1): 6–12. DOI: 10.4103/ijstd.IJSTD_23_19

12. Aide S., Lattario F.R., Almeida G., et al. Epstein-Barr virus and human papillomavirus infection in vulvar lichen sclerosus. J Low Genit Tract Dis. 2010; 14 (4): 319–22.

13. Nasca M.R., Lacarrubba F., Micali G. Human papillomavirus infection and lichen sclerosus: coincidence or link? Int J Dermatol. 2018; 57: 611–24.

14. Oyama N. Current Understanding of Molecular-based Immunopathology in Lichen Sclerosus. International Trends in Immunity. 2015: 6.

15. Dvornikov A.S. Treatment of localized scleroderma with hyaluronidase. Vestnik dermatologii and venerologii [Bulletin of Dermatology and Venereology]. 2013; (3): 96–100. DOI: https://doi.org/10.25208/vdv627 (in Russian)

16. Paulis G., Berardesca E. Lichen sclerosus: the role of oxidative stress in the pathogenesis of the disease and its possible transformation into carcinoma. Res Rep Urol. 2019; 20 (11): 223–32. DOI: 10.2147/RRU.S205184

17. Basheer S., Shameena P.M., Sudha S., et al. Expression of survivin and p53 in oral lichen planus, lichenoid reaction and lichenoid dysplasia: An immunohistochemical study. J Oral Maxillofac Pathol. 2017; 21 (3): 456–7. DOI: 10.4103/jomfp.JOMFP_39_15

18. Batyrovа Z.K., Uvarova E.V., Kolodkina A.A., Latypova N.Kh Some aspects of diagnosis and choice of treatment measurement of children with vulvar lichen sclerosus

Reproduktivnoe zdorov’e detey detey i podrostkov [Pediatric and Adolescent Reproductive Health]. 2016; 5: 34–8. (in Russian)

19. Fruchter R., Melnick L., Pomeranz M.K. Lichenoid vulvar disease: a review. Int J Womens Dermatol. 2017; 3 (1): 58–64. DOI: 10.1016/j.ijwd.2017.02.017

20. Berger M.B., Damico N.J., Menees S.B. et al. Rates of self-reported urinary, gastrointestinal, and pain comorbidities in women with vulvar lichen sclerosus. J Low Genit Tract. 2012;16 (3): 285–9.

21. Kirtschig G. Lichen Sclerosus-Presentation, Diagnosis and Management. 2016; 113 (19): 337–43. DOI: 10.3238/arztebl.2016.0337

22. Khaitan B.K. In: Nonvenreal diseases of genitalia. Sexually Transmitted Diseases and AIDS. 1st ed. Sharma VK, New Delhi: Viva Books Pvt. Ltd. 2003. Р. 413–21.

23. Bornstein J.Vulvar Disease: Breaking the Myths. 2019. DOI: 10.1007/978-3-319-61621-6

24. Lacarrubba F., Pellacani G., Verzì A.E., et al. Extragenital lichen sclerosus: Clinical, dermoscopic, confocal microscopy and histologic correlations. J Am Acad Dermatol. 2015; 72 (1): 50–2.

25. Rakislova N., Alemany L., Clavero O., et al. p53 Immunohistochemical patterns in hpv-independent squamous cell carcinomas of the vulva and the associated skin lesions: a study of 779 cases. Int J Mol Sci. 2020; 21: 8091. DOI: https://doi.org/10.3390/ijms21218091

26. Corazza M., Borghi A., Minghetti S., et al. Clobetasol propionate vs. mometasone furoate in 1-year proactive maintenance therapy of vulvar lichen sclerosus: Results from a comparative trial. J Eur Acad Dermatol Venereol (JEADV). 2016; 30 (6): 956–61. DOI: https://doi.org/10.1111/jdv.13166 PMID: 25904498.

27. Sokolova A.V., Apolikhina I.A. Treatment for female external genital lichen sclerosus: from standards to innovations. Akusherstvo i ginekologiya [Obstetrics and Gynecology]. 2020; (7): 37–46. (in Russian). URL: https://dx.doi.org/10.18565/aig.2020.7.37-46 (in Russian)

28. Oikarinen A. Systemic estrogens have no conclusive beneficial effect on human skin connective tissue. Acta Obstet Gynecol Scand. 2009; 79 (4): 250–4. DOI: https://doi.org/10.1080/j.1600-0412.2000.079004250.x

29. Clinical recommendations «Sclerotic and atrophic lichen». In: All-Russian public organization «Russian Society of Dermatovenereologists and Cosmetologists». Moscow, 2020. (in Russian)

30. Hennge U.R. Lichen sclerosus. In: K. Wolf, L.A. Goldmit, S.I. Katz, et al. (eds); Transl. from Engl.; Gen. ed. A.A. Kubanova. Fitzpatrick’s Dermatology in Clinical Practice: In 3 vols. Moscow: Izdatel’stvo Panfilova; BINOM. Laboratoriya znaniy, 2012; (1): 598–602. (in Russian)

31. Krapf J.M., Mitchell L., Holton M.A., et al. Vulvar lichen sclerosus: current perspectives. Int J Womens Health. 2020; 12: 11–20. DOI: https://doi.org/10.2147/IJWH.S191200

32. Karabut М.М., Gladkova N.D., Fel’dshteyn F.I. Fractional laser photothermolysis in the treatment of skin defects: possibilities and effectiveness (review). Sovremennye tekhnologii v meditsine [Modern Technologies in Medicine]. 2016; 8 (2): 98–108. DOI: https://doi.org/10.17691/stm2016.8.2.14 (in Russian)

33. Apolikhina I.A., Sokolova A.V., Balashov I.S., Chernukha L.V., Ermakova E.I. Treatment vulvar lichen sclerosus with fractional CO2-laser: cohort clinical study. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie [Obstetrics and Gynecology: News, Opinions, Training]. 2020; 8 (2): С. 48–58. DOI: https://doi.org/10.24411/2303-9698-2020-12004 (in Russian)

34. Tan Q., Li J., Yin Y. The role of growth factors in the repair of motor injury. Front Pharmacol. 2022; 19 (13): 898152. DOI: https://doi.org/10.3389/fphar.2022.898152

35. Turzi Antoine & REGEN LAB Team. Biobridge Foundation Editions. PRP Standardisation & Cells Therapies. Lausanne, Switzerland, 2018: 96 p.

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CHIEF EDITORS
CHIEF EDITOR
Sukhikh Gennadii Tikhonovich
Academician of the Russian Academy of Medical Sciences, V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Moscow
CHIEF EDITOR
Kurtser Mark Arkadievich
Academician of the Russian Academy of Sciences, MD, Professor, Head of the Obstetrics and Gynecology Subdepartment of the Pediatric Department, N.I. Pirogov Russian National Scientific Research Medical University, Ministry of Health of the Russian Federation
CHIEF EDITOR
Radzinsky Viktor Evseevich
Corresponding Member of the Russian Academy of Sciences, MD, Professor, Head of the Subdepartment of Obstetrics and Gynecology with a Course of Perinatology of the Medical Department in the Russian People?s Friendship University

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