Obesity is a risk factor of recurrent miscarriage

• Sergey A. Mikhalev
• Diana N. Masalimova

Abstract

Despite numerous scientific studies on the analysis of the causes of recurrent miscarriage, up to 40% of risk factors remain uncertain/unknown. This circumstance determined the direction of our study.

The aim of the study was to analyze and summarize the scientific data accumulated to date on the pathogenesis of recurrent miscarriage in obese women.

Material and methods. A search was made for scientific publications for 2012–2022 in the Cochrane Library, Science Direct, PubMed, ELibrary databases using the keywords: pathogenesis, miscarriage, obesity, risk factor. Obesity is a key trigger in the pathogenesis of recurrent miscarriage in women of fertile age.

Conclusion. To date, the pathogenesis has not been fully disclosed, which makes it difficult to predict the outcomes of the above disorders. There is an obvious need for well-designed, high-quality studies whose results will allow development of effective patient management algorithms and improve reproductive/perinatal outcomes.

Conflict of interest. The authors declare the absence of obvious and potential conflicts of interest related to the publication of this article.

Funding. The authors declare the absence of external funding for the study and publication of the article.

Contribution. The authors declare the compliance of their authorship according to the international ICMJE criteria. All authors made a substantial contribution to the conception of the work, acquisition, analysis, interpretation of data for the work, drafting and revising the work, final approval of the version to be published and agree to be accountable for all aspects of the work.

Keywords:miscarriage; obesity; risk factor; maternal obesity; high body mass index

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