Immuno-biochemical features of homeostasis in obese pregnant women

• Nozimabonu M. Zokirova
• Agamurad A. Orazmuradov
• Anastasiya N. Akhmatova
• Zhasmina Zh. Suleymanova
• Sergey G. Morozov
• Juliya V. Krylova

Abstract

The aim of the study was to study the immunobiochemical features of homeostasis in pregnant women with varying degrees of obesity.

Material and methods. 71 pregnant women with obesity were examined. All the examined patients were divided into 3 groups, depending on the body mass index (BMI) and the corresponding degree of obesity. The 1^st group included patients with obesity of the I degree (n=32), in the 2^nd – with obesity of the II degree (n=20), in the 3^rd – pregnant women with obesity of the III degree (n=19).

Results. When comparing the lipid profile of pregnant women with different degrees of obesity, statistically significant differences in concentrations of cholesterol and triglycerides were revealed in pregnant women with obesity of III, I, II degrees. When comparing the indicators of biochemical blood analysis in pregnant women with different degrees of obesity, there were no statistically significant differences between the groups. In all the studied groups, the majority of patients showed a shift in immunoreactivity towards hyporeactivity. The revealed hyperreactivity in pregnant women of groups 1^st and 3^rd is evidence of immunity tension, which can be explained by possible presence of autoimmune diseases.

Keywords:obesity; pregnancy; lipid profile; immunoreactivity; ELI-P-test-1; cholesterol

REFERENCES

1. Seregina D.S., Nikolaenkov I.P., Kuzminykh T.U. Obesity is a leading pathogenetic link in the pathological course of pregnancy and childbirth. Zhurnal akusherstva i zhenskikh bolezney [Journal of Obstetrics and Women’s Diseases]. 2020; 69 (2): 73–82. DOI: https://doi.org/10.17816/JOWD69273-82 (in Russian)

2. Andreeva E.N., Sheremet’eva E.V., Fursenko V.A. Obesity – a threat to Russia’s reproductive potential. Ozhirenie i metabolism [Obesity and Metabolism]. 2019; 16 (3): 20–8. DOI: https://doi.org/10.14341/omet10340 (in Russian)

3. Ellulu M.S., Patimah I., Khaza’ai H., Rahmat A., Abed Y. Obesity and inflammation: the linking mechanism and the complications. Arch Med Sci. 2017; 13 (4): 851–63.

4. Veselovskaya N.G., Chumakova G.A. Obesity and pregnancy: cardiovascular and metabolic risks. Rossiyskiy kardiologicheskiy zhurnal [Russian Journal of Cardiology]. 2019; 24 (4): 48–52. (in Russian)

5. Buzzaccarini G., Vitagliano A., Andrisani A., Santarsiero C.M., Cicinelli R., Nardelli C., et al. Chronic endometritis and altered embryo implantation: a unified pathophysiological theory from a literature systematic review. J Assist Reprod Genet. 2020; 37 (12): 2897–911. DOI: https://doi.org/10.1007/s10815-020-01955-8

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)