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4 . 2022

Brain-derived neurotrophic factor (BDNF) as a new way to diagnose severe preeclampsia

Abstract

The aim of the study was to develop a method for diagnosing severe preeclampsia based on the determination of the quantitative content of brain-derived neurotrophic factor (BDNF) in blood serum.

Material and methods. The study included 91 pregnant women, including 80 women with various forms of hypertensive disorders [chronic arterial hypertension, gestational arterial hypertension, preeclampsia (moderate, severe], HELLP syndrome) – the study group. The comparison group consisted of 11 pregnant women without hypertensive disorders and without proteinuria. The control group consisted of 11 relatively healthy non-pregnant women, without signs of arterial hypertension. In the blood serum of pregnant women, the concentration of BDNF was determined by ELISA.

Results. In pregnant women with hypertensive disorders in the gestation period of 22–40 weeks, the level of BDNF in the serum of peripheral venous blood was determined. If its levels were ≥6.8 ng/ml the authors diagnosed severe preeclampsia, and at a value of 11.1 ng/ml, HELLP syndrome was diagnosed.

Keywords:pregnancy; preeclampsia; HELLP syndrome; brain-derived neurotrophic factor (BDNF)

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

For citation: Kondratyuk I.V., Padrul M.M., Karakulova Yu.V. Brain-derived neurotrophic factor (BDNF) as a new way to diagnose severe preeclampsia. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie [Obstetrics and Gynecology: News, Opinions, Training]. 2022; 10 (4): 13–7. DOI: https://doi.org/10.33029/2303-9698-2022-10-4-13-17 (in Russian)

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CHIEF EDITORS
CHIEF EDITOR
Sukhikh Gennadii Tikhonovich
Academician of the Russian Academy of Medical Sciences, V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Moscow
CHIEF EDITOR
Kurtser Mark Arkadievich
Academician of the Russian Academy of Sciences, MD, Professor, Head of the Obstetrics and Gynecology Subdepartment of the Pediatric Department, N.I. Pirogov Russian National Scientific Research Medical University, Ministry of Health of the Russian Federation
CHIEF EDITOR
Radzinsky Viktor Evseevich
Corresponding Member of the Russian Academy of Sciences, MD, Professor, Head of the Subdepartment of Obstetrics and Gynecology with a Course of Perinatology of the Medical Department in the Russian People?s Friendship University

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