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4 . 2022

Complicated pregnancy with a combination of immune thrombocytopenia and new coronavirus infection

Abstract

Immune thrombocytopenia in pregnancy (ITP) and a new coronavirus infection caused by SARS-CoV-2 is classified as a high-risk group for the probability of hemorrhagic complications in both the mother and the newborn. Currently, the exact mechanism of immune impairment in COVID-19 is unknown, so the greatest attention should be paid to patients who already have a pathology of autoimmune etiology. Obstetric and perinatal risks in ITP have been extensively discussed in the studies. In the present article, we have analyzed data from domestic and foreign literary sources, citing clinical cases of a complicated course of immune thrombocytopenia in pregnant women with a new coronavirus infection. Our studies suggest that SARS-CoV-2 infection with severe ITP contributes to a severe course of the disease, including cases with a lethal outcome. The mechanism is due to changes in hemostasis, direct damage to the vascular endothelium, causing its dysfunction and associated impaired clotting potential. The severity of the course of ITP in pregnant women and unsatisfactory perinatal outcomes depend on the severity of clinical manifestations and COVID-19 severity.

Keywords:immune thrombocytopenia; new coronavirus infection; pregnancy; clinical case

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

For citation: Rumyantseva Z.S., Dizha M.A., Miklin O.P., Kondratyuk D.V., Ermachkova P.A., Kravchenko A.N. Complicated pregnancy with a combination of immune thrombocytopenia and new coronavirus infection. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie [Obstetrics and Gynecology: News, Opinions, Training]. 2022; 10 (4): 6–12. DOI: https://doi.org/10.33029/2303-9698-2022-10-4-6-12 (in Russian)

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CHIEF EDITORS
CHIEF EDITOR
Sukhikh Gennadii Tikhonovich
Academician of the Russian Academy of Medical Sciences, V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Moscow
CHIEF EDITOR
Kurtser Mark Arkadievich
Academician of the Russian Academy of Sciences, MD, Professor, Head of the Obstetrics and Gynecology Subdepartment of the Pediatric Department, N.I. Pirogov Russian National Scientific Research Medical University, Ministry of Health of the Russian Federation
CHIEF EDITOR
Radzinsky Viktor Evseevich
Corresponding Member of the Russian Academy of Sciences, MD, Professor, Head of the Subdepartment of Obstetrics and Gynecology with a Course of Perinatology of the Medical Department in the Russian People?s Friendship University

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