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3 . 2022

Phytoestrogens ("Femo-Klim") and psychological state in women with hypoestrogenism and abdominal obesity

Abstract

77 women with preserved regular menstrual cycles and metabolically healthy abdominal obesity in the early period of the menopausal transition were examined. Certain psychological changes were identified. It has been established that Femo-clim (the complex of amino acids, vitamin B6 and phytoestrogens) effectively affects the psychological state of women with metabolically healthy obesity (in early period of menopausal transition). The drug “Femo-Klim” eliminates psycho-vegetative clinical manifestations of menopausal transition.

Keywords:metabolically healthy obesity; psychological state; menopausal transition; phytoestrogens; klimalanin; vitamin B6

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

For citation: Khabibulina M.M., Shamilov M.D. Phytoestrogens ("Femo-Klim") and psychological state in women with hypoestrogenism and abdominal obesity. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie [Obstetrics and Gynecology: News, Opinions, Training]. 2022; 10 (3): 107–12. DOI: https://doi.org/10.33029/2303-9698-2022-10-3-107-112 (in Russian)

REFERENCES

1. Shevchenko O.P., Praskurnichy E.A., Shevchenko A.O. Metabolic syndrome. Moscow: Reafarm, 2004. (in Russian)

2. Barbato J.E., Zuckerbraun B.S., Overbaus M., et al. Nitric oxide modulates vascular inflammation and intimal hyperplasia in insulin resistance and metabolic syndrome. J Physiol Heart Circ. 2005; 289: 228–36.

3. De Fronzo R.A., Ferranini E. Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic disease. Diabetes Care. 1991; Vol. 14: 173–94.

4. Dupuy A.M., Carriere L., Scali J., et al. Lipid levels and cardiovascular risk in elderly women: a general population study of the effects of hormonal treatment and lipid-lowering agents. Climacteric. 2008; 11: 74–83.

5. Rabmouni K., Correia M.L.G., Haynes W.G., et al. Obesity-associated hypertension. New insights into mechanisms. Hypertension. 2005; 45: 9–14.

6. Khabibulina M.M., Dmitriev A.N., Fedorova N.N. Silent myocardial ischemia in women with arterial hypertension with hypestrogenism in the late fertile period with «metabolically healthy» visceral obesity. Interaktivnaya nauka [Interactive Science]. 2017; (12): 81–3. (in Russian)

7. Khabibulina M.M., Dmitriev A.N., Fedorova N.N. Quality of life of young women with arterial hypertension with hypoestrogenemia with «metabolically healthy» visceral obesity. Evraziyskiy soyuz uchonikh [Euroasian Scientists Union]. 2017; 1 (34): 25–9. (in Russian)

8. Khabibulina M.M., Dmitriev A.N., Fedorova N.N. Atarax treatment of anxiety disorders in women with arterial hypertension with hypoestrogenemia in the late fertile period with «metabolically healthy» obesity. In: Materials of the Educational Forum «Russian Heart Days». Moscow, 2017: 35–6. (in Russian)

9. Anan’ev V.A. Features of a discrete personality type in the etiopathogenesis of psychosomatic disorders. Vestnik psykhoterapii [Bulletin of Psychotherapy]. 2003; 10 (15): 45–55. (in Russian)

10. Kulakov S.A. Fundamentals of psychosomatics. Saint Petersburg: Rech’, 2003: 288 p. (in Russian)

11. Eydemiller E.G., Yustitskis V. Psychology and psychotherapy of the family. 2nd ed., expanded, add. Saint Petersburg, 2005: 656 p. (in Russian)

12. Rotov A.V., Gavrilov M.A., Bobrovsky A.V., Gudkov SV. Aggression as a form of adaptive psychological defense in women with overweight. Sibirskiy vestnik psikhiatrii i narkologii [Siberian Bulletin of Psychiatry and Narcology]. 1999; (1): 81–3. (in Russian)

13. Alam I., Ng T.P., Larbi A. Does inflammation determine whether obesity is metabolically healthy or unhealthy? The aging perspective. Mediators Inflamm. 2012; 2012: 456456.

14. Romantsova T.I., Ostrovskaya E.V. Metabolically healthy obesity: definitions, protective factors, clinical relevance. Al’manakh klinicheskoy meditsiny [Almanac of Clinical Medicine]. 2015; 13 (21): 75–87. (in Russian)

15. Vliet-Ostaptchouk J.V., Nuotio M.L., Slagter S.N. The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: a collaborative analysis of ten large cohort studies. BMC Endocr Disord. 2014; 14: 9.

16. Bobrovsky A.V., Rotov A.V., Gudkov S.V., Romashova O.A. Relationship between psychological characteristics of personality and body weight in patients with exogenous constitutional obesity. Sibirskiy psikhologicheskiy zhurnal [Siberian Journal of Psychology]. 1998; (8–9): 84–5. (in Russian)

17. Voznesenskaya T.G., Dorozhevets A.N. The role of personality traits in the pathogenesis of cerebral obesity. Sovetskaya meditsina [Soviet Medicine]. 1987; (3): 28–32. (in Russian)

18. Ryden A., Sullivan M., Torgerson J.S., Karlsson J., Lindroos A.K., Taft C. Severe obesity and personality: a comparative controlled study of personality traits. Int J Obes. 2003; 27 (12): 1534–40.

19. Khabibulina M.M. Effect of hypoestrogenemia on quality of life of premenopausal women with arterial hypertension. Kardiologiya [Cardiology]. 2013; 53 (11): 45–8. (in Russian)

20. Khabibulina M.М., Shamilov M.D. Quality of life in young women with hypertension and an altered hormonal background. Vrach [Physician]. 2021; 32 (1): 46–9. (in Russian)

21. Blumel J.E., Castello C. et al. Quality of life after the menopause – a population study // Maturitas. 2009. Vol. 34. P. 17–23.

22. Stein K.D., Jacobsen P.B. Impact of hot flashes on quality of life among postmenopausal women being treated for breast cancer. J Pain Symptom. 2009; 19: 436–45.

23. Khabibulina M.M. Cardiovascular risk in estrogen deficiency in premenopausal periods. Ekaterinburg, 2014. (in Russian)

24. Khabibulina M.M., Smolentseva A.A. Therapy of anxiety disorders in women with premenopausal arterial hypertension at the outpatient stage. In: V Congress of Cardiologists of the Ural Federal District. Congress Materials. Ekaterinburg, 2011: 282–4. (in Russian)

25. Skornyakova M.N., Syrochkina M.A. Hypomenstrual syndrome. Guide for doctors. Ekaterinburg, 2008: 236 p. (in Russian)

26. Smetnik V.P., Il’yina L.M. Correction of the climacteric syndrome (individualization of therapy). In: Medicine of Menopause. Yaroslavl’: Litera, 2006: 217–74. (in Russian)

27. Ilovayskaya I.A., Woytaszewsky K.V. Menopausalis hormone therapy: occasiones et pericula. StatusPraesens. Ginekologiya. Akusherstvo. Besplodniy brak [StatusPraesens. Gynecology. Obstetrics. Barren Marriage]. 2015; 5 (28): 80–6. (in Rus- sian)

28. Menopause and climacteric condition in women. Clinical recommendations Moscow: FGBU NTsGAiP, 2021. (in Russian)

29. Sturdee D.W., Pines A. Updated IMS recommendations on postmenopausal hormone therapy and preventive strategies for midlife health. Climacteric. 2011; 14: 302–20. DOI: https://doi.org/10.3109/13697137.2011.570590

30. Khabibulina M.M., Dmitriev A.N. A method for optimizing the treatment of women with cardiotropic therapy and hormone replacement therapy for estrogen deficiency with arterial hypertension in the late reproductive period. Patent for invention RU 2648470 C2, 03/26/2018. Application No. 2016107890 dated 03.03.2016.31. (in Russian)

31. Khabibulina M.M. Therapy in women with hypertension and estrogen deficiency in the late fertile period. Vrach [Physician]. 2016; (4): 45–9. (in Russian)

32. Van Strien T., Herman C.P., Verheijden M.W. Eating style, overeating, and overweight in a representative Dutch sample: does external eating play a role? Appetite. 2008; 52 (2): 380–7.

33. Khanin Yu.L. A brief guide to the use of the scale of reactive and personal anxiety Ch.D. Spielberger. Leningrad, 1976: 40 p. (in Russian)

34. Speilberger C., Gorusch R., Lushene R. Test Manual for the State-Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press, 1970: 280 р.

35. Ovsyannikova T.V., Makarov I.A., Kulikov I.A. Orciefficacia non-hormonal therapies in mulieribus in perimenopausal mulieres. Akusherstvo, ginekologiya, reproduktologiya [Obstetrics, Gynecology, Reproductology]. 2013; 7 (3): 26–9. (in Rus- sian)

36. Petrova E., Kalistratov V., Poluboyarinov P., Strukov V., Prokhorov M., Elis- tratov D. The menopause drug femo-klim is the best nonhormonal solution of hormonal problems. Vrach [Physician]. 2019; (1): 46–9. DOI: https://doi.org/10.29296/2 5877305-2019-01-08 (in Russian)

37. Radzinsky V.E., Dobretsova T.A. Menopause as a mechanism of female aging. Phytoestrogens – combat exploration. StatusPraesens. Ginekologiya. Akusherstvo. Besplodniy brak [StatusPraesens. Gynecology. Obstetrics. Barren Marriage]. 2015; 2 (25): 51–8. (in Russian)

38. Tatarova N.A., Linde V.A., Zhidkova E.V., Sokhadze H.S. Non-hormonal correction of climacteric disorders in peri- and postmenopause. Effektivnaya farmakoterapiya v akusherstve i ginekologii [Effective Pharmacotherapy in Obstetrics and Gynecology]. 2009; (17): 12–5. (in Russian)

39. Khamoshina M.B., Rogovskaya S.I., Naumchik G.A. Current possibilities of pharmacology in the prevention of age-related disorders. StatusPraesens. Ginekologiya. Akusherstvo. Besplodniy brak [StatusPraesens. Gynecology. Obstetrics. Barren Marriage]. 2014; 1 (18): 75–81. (in Russian)

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CHIEF EDITORS
CHIEF EDITOR
Sukhikh Gennadii Tikhonovich
Academician of the Russian Academy of Medical Sciences, V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Moscow
CHIEF EDITOR
Kurtser Mark Arkadievich
Academician of the Russian Academy of Sciences, MD, Professor, Head of the Obstetrics and Gynecology Subdepartment of the Pediatric Department, N.I. Pirogov Russian National Scientific Research Medical University, Ministry of Health of the Russian Federation
CHIEF EDITOR
Radzinsky Viktor Evseevich
Corresponding Member of the Russian Academy of Sciences, MD, Professor, Head of the Subdepartment of Obstetrics and Gynecology with a Course of Perinatology of the Medical Department in the Russian People?s Friendship University

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