To the content
2 . 2022

Immunotherapy of postmenopausal osteoporosis and other osteoarticular diseases against the background of hormonal deficiency

Abstract

Possibilities of using immunotherapy in therapy of postmenopausal osteoporosis and other osteoarticular diseases that develop against the background of sex hormones deficiency in climacteric period are presented. The article discusses the relationship between the osteoarticular and immune systems of the body; provides specific results of the clinical use of “Osteomed”, “Osteo-Vit D3”, and “Osteomed Forte” supplements in order to maximize the physiological restoration of impaired balance between bone resorption and osteogenesis.

Keywords:postmenopausal osteoporosis; immunotherapy; mesenchymal stem cells; Osteo-Vit D3; Osteomed; Osteomed Forte

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

For citation: Strukov V.I., Vinogradova O.P., Sergeeva-Kondrachenko M.Yu., Marchenkova L.A., Elistratov D.G. Immunotherapy of postmenopausal osteoporosis and other osteoarticular diseases against the background of hormonal deficiency. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie [Obstetrics and Gynecology: News, Opinions, Training]. 2022; 10 (1): 47–55. DOI: https://doi.org/10.33029/2303-9698-2022-10-2-47-55 (in Russian)

REFERENCES

1. Faienza M.F., Ventura A., Cavallo L. Postmenopausal osteoporosis: the role of immune system cells. Clin Dev Immunol. 2013; 2013: 575936.

2. Kuptsova T., Kislov A., Strukov V., Balykova L., Maksimova M., Agafonov D., et al. Osteo-Vit D3 in the treatment of children with repeated bone fractures during osteoporosis. Vrach [Physician]. 2016; (1): 46–7. (in Russian)

3. Osadchiy A., Zel’ter P. Dual-energy X-ray absorptiometry in evaluating the efficiency of osteopenia treatment. Vrach [Physician]. 2015; (11): 79–80. (in Russian)

4. Krum S.A. Direct transcriptional targets of sex steroid hormones in bone. J Cell Biochem. 2011; 112 (2): 401–8.

5. Porovoznyuk V.V., Grigor’eva N.V. Menopause and osteoporosis. Reproduktivnaya endokrinologiya [Reproductive Endocrinology]. 2012; (2): 40–7. (in Russian)

6. Tok E.C., Ertunc D., Oz U., Camdeviren H., Ozdemir G., Dilek S. The effect of circulating androgens on bone mineral dencity in postmenopausal women. Maturitas. 2004; 48 (3): 235–42.

7. Abu E.O., Horner A., Kusec V., Triffitt J.T. The localization of androgen receptors in human bone. J Clin Endocrinol Metab. 1997; 82 (10): 3493–7.

8. Caetano-Lopes J., Canhao H., Fonseca J.E. Osteoimmunology – the hidden immune regulation of bone. Autoimmun Rev. 2009; 8 (3): 250–5.

9. Geusens P., Lems W.F. Osteoimmunology and osteoporosis. Arthritis Res Ther. 2011; 13 (5): 242.

10. Wu Y., Humphrey M.B., Nakamura M.C. Osteoclasts – the innate immune cells of the bone. Autoimmunity. 2008; 41 (3): 183–94.

11. Terpos E., Dimopoulos M.A. Interaction between the skeletal and immune systems in cancer: mechanisms and clinical implications. Cancer Immunol Immunother. 2011; 60 (3): 305–17.

12. Lorenzo J., Horowitz M., Choi Y. Osteoimmunology: interactions of the bone and immune system. Endocr Rev. 2008; 29 (4): 403–40.

13. Mohamed S.G., Sugiyama E., Shinoda K., et al. Interleukin-10 inhibits RANKL-mediated expression of NFATc1 in part via suppression of c-Fos and c-Jun in RAW264.7 cells and mouse bone marrow cells. Bone. 2007; 41 (4): 592–602.

14. Janssens K., Dijke P., Janssens K., et al. Transforming growth factor-131 to the bone. Endocr Rev. 2005; 26 (6): 743–74.

15. Rifas L., Arackal S., Weitzmann M.N. Inflammatory T cells rapidly induce differentiation of human bone marrow stromal cells into mature osteoblasts. J Cell Biochem. 2003; 88 (4): 650–9.

16. Quinn J.M. Gillespie M.T. Modulation of osteoclast formation. Biochem Biophys Res Commun. 2005; 328 (3): 739–45.

17. Rossouw J.E., Anderson G.L., Prentice R.L., et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA. 2002; 288 (3): 321–33.

18. Zhao C., Irie N., Takada Y., et al. Bidirectional Ephrin B2-Eph B4 signaling controls bone homeostasis. Cell Metab. 2006; 4 (2): 111–21.

19. Matsuo K., Irie N. Osteoclast-osteoblast communication. Arch Biochem Biophys. 2008; 473 (2): 201–9.

20. Ryu J., Kim H.J., Chang E.J., et al. Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling. EMBO J. 2006; 25 (24): 5840–51.

21. Luckman S.P., Hughes D.E., Coxon F.P., et. al. Nitrogen-containing bisphosphonates inhibit mevalonate pathway and prevent posttranslational prenylation of GTP-binding proteins, including Ras. J Bone Miner Res. 1998; 13 (4): 581–9.

22. Giusti A., Hamdy N.A., Papapoulos S.E. Atypical fractures of the femur and bisphosphonate therapy. A systematic review of case/case series studies. Bone. 2010; 47 (2): 169–80.

23. Lenart B.A., Neviaser A.S., Lyman S., Chang C.C., Edobor-Osula F., Steele B., et al. Association of low-energy femoral fractures with prolonged bisphosphonate use: a case control study. Osteoporos Int. 2009; 20 (8): 1353–62.

24. Girgis C.M., Seibel M.J. Bisphosphonate use and femoral fractures in older women. JAMA. 2011; 305: 2068–74.

25. Scholes D., LaCroix A.Z., Hubbard R.A., Ichikawa L.E., Spangler L., Operskalski B.H., et al. Oral contraceptive use and fracture risk around the menopausal transition. Menopause. 2016; 23 (2): 166–74.

26. Vasilenko Yu.K., Klimova O.V., Lazaryan D.S. Biological effect of drone brood under chronic hyperlipidemia conditions. Khimiko-farmatsevticheskiy zhurnal [Pharmaceutical Chemistry Journal]. 2002; 36 (8): 34–6. (in Russian)

27. Krylov V.N., Agafonov A.V., Krivtsov N.I., Lebedev V.I., Burmistrova L.A., Oshevensky L.V., et al. Theory and remedies of apitherapy. Moscow: GU NIIP Rossel’khozakademiya, 2007. (in Russian)

28. Vasilenko Yu.K., Klishina I.I., Lazaryan D.S. A comparative study of the immunotropic action of beekeeping products in rats with drug-induced hepatitis. Khimiko-farmatsevticheskiy zhurnal [Pharmaceutical Chemistry Journal]. 2005; 39 (6): 36–8. (in Russian)

29. Sawczuk R., Karpinska J., Miltyk W. What do we know and what we would like to know about drone homogenate. J Ethnopharmacol. 2019; 245: 111581.

30. Isidorov V.A., Bakier S., Stocki M. GC-MS investigation of the chemical composition of honey bee drone and queen larva homogenate. J Apic Sci. 2016; 60 (1): 33–8.

31. Goldring S.R. Inflammatory signaling induced bone loss. Bone. 2015; 80: 143–9.

32.Knizhenko V.A., Elkin V.A. Medicines from beehive. Khar’kov: Klub semeynogo dosuga, 2017: 14 p. (in Russian)

33. Karomatov I.D. Drone brood as medicine (literature review). Biologiya i integrativnaya meditsina [Biology and Integrative Medicine]. 2020; 4 (44): 85–101. (in Russian)

34. Tsapenko Yu.P., Boyko N.G., Grechka G.N., Nosik N.I., Kraevskaya A.A. The effect of apiproducts on immunological performance in patients with firstly identified infiltrative pulmonary tuberculosis. Tuberkulez, legochnye bolezni, VICh-infektsiya [Tuberculosis, Pulmonary Diseases, HIV-Infection]. 2012; 3 (10): 17–21. (in Russian)

35. Klishina I.I. The effect of drone brood on the activity of non-specific resistance factors and the functional of the liver during acute intoxication: Diss. Pyatigorsk, 2003. (in Russian)

36. Burmistrova L.A. Physicochemical analysis and biochemical evaluation of the biological activity of drone brood: Diss. Rybinsk, 1999. (in Russian)

37. Corotchi M.C., Popa M.A., Simionescu M. Testosterone stimulates proliferation and preserves stemness of human adult mesenchymal stem cells and endothelial progenitor cells. Rom J Morphol Embryol. 2016; 57 (1): 75–80.

38. Snopov S.A. Mechanisms of the action of vitamin D on the immune system. Meditsinskaya immunologiya [Medical Immunology]. 2014; 16 (6): 499–530. (in Russian)

39. Maylyan E.A., Reznichenko N.A., Maylyan D.E. The role of vitamin D in the regulation of anti-infective immunity. Krymskiy zhurnal eksperimental’noy i klinicheskoy meditsiny [Crimea Journal of Experimental and Clinical Medicine]. 2016; 6 (4): 75–82. (in Russian)

40. Pigarova E.A., Petrushkina A.A. Non-classic effects of vitamin D. Osteoporoz i osteopatii [Osteoporosis and Osteopathy]. 2017; 20 (3): 90–101. (in Russian)

41. Ivanyuk D.I., Turchin V.V., Popandopulo A.G., Grin’ V.K. Mechanisms of the immunomodulating action of mesenchymal stem cells. Kletochnaya transplantologiya i tkanevaya inzheneriya [Cell Transplantation and Tissue Engineering]. 2011; 6 (2): 27–31. (in Russian)

42. Casciato D.A., McAdam L.P., Kopple J.D., Bluestone R., Goldberg L.S., Clements P.J., et al. Immunologic abnormalities in hemodialysis patients: improvement after pyridoxine therapy. Nephron. 1984; 38 (1): 9–16.

43. Folkers K., Morita M., McRee J.J. The activities of coenzymeQ10 and vitamin B6 for immune responses. Biochem Biophys Res Commun. 1993; 193 (1): 88–92.

44. Talbott M.C., Miller L.T., Kerkvliet N.I. Pyridoxine supplementation: effect on lymphocyte responses in elderly persons. Am J Clin Nutr. 1987; 46 (4): 659–64.

45. Spirichev V.B. Vitamins and minerals in complex prevention and treatment of osteoporosis. Voprosy pitaniia [Problems of Nutrition]. 2003 (1): 34–43. (in Russian)

46. Yurova O., Marchenkova L. The experience of using of comprehensive rehabilitation program with dietary supplements Osteomed Forte in patients with an osteoporotic distal forearm fracture. Vrach [Physician]. 2020; (2): 47–50. (in Russian)

47. Strukov V.I., Elistratov D.G., Shcherbakova Yu.G., Kuptsova T.A., Galeeva R.T., Radchenko L.G., et al. Osteo-Vit D3 in the treatment of children with repeated fractures and low bone mineral density. Meditsinskaya sestra [Nurse]. 2014; (7): 44–6. (in Russian)

48. Polikarpochkin A.N., Levshin I.V., Vovk E.V., Strukov V.I., Raskachkin V.A., Tokarev A.V. Evaluation of the efficacy of hyperbaric oxygen therapy and «Osteo-Vit D3» in the treatment of gonarthrosis. [Geperbaricheskaya fiziologiya i meditsina [Hyperbaric Physiology and Medicine]. 2018; (1): 13–24. (in Russian)

49. Prokhorov M., Kislov A. Elistratov D., Strukov V., Kuptsova T., Nikanova E., et al. Effect of Osteomed on consolidation of bone fractures. Vrach [Physician]. 2016; (2): 68–9. (in Russian)

50. Konshu N. Combination therapy for joint hypermobility syndrome. Vrach [Physician]. 2015; (12): 38–40. (in Russian)

51. Strukov V., Elistratov D., Katyushina Yu., Filippova O., Maksimova M., Radchenko L. The effect of hormone deficiency on bone tissue. New approaches to the treatment of presenile and senile osteoporosis. URL: https://osteomed.su/lechenie-presenilnogo-i-senilnogo-osteoporoza/

52. Peshekhonova L.K., Peshekhonov D.V., Krasyukov P.A. The clinical efficiency of using Osteomed, Osteomed Forte and Osteo-Vit D3 in patients with secondary osteoporosis in rheumatoid arthritis. Vrach [Physician]. 2020; (4): 68–74. (in Russian)

53. Strukov V.I., Prokhorov M.D., Elistratov D.G. The method of decreasing the immobilization terms in bone fractures. Mezhdunarodniy zhurnal prikladnykh i fundamental’nykh issledovaniy [International Journal of Applied and Fundamental Research]. 2013; (9): 124–6. (in Russian)

54. Strukov V.I., Katyushina Yu.G., Eremina N.V., Filippova O.V. Osteomed – effective regulator of bone mineral density and closure of cavity formations in the treatment of presenile and senile osteoporosis. Poliklinika [Policlinic]. 2013; (1): 90–1. (in Russian)

55. Raskachkin V., Tokarev A., Panov I. The biologically active agent Osteomed in the combination treatment of large joints arthrosis. Vrach [Physician]. 2017; (3): 37–40. (in Russian)

56. Strukov V., Elistratov D., Balykova L., Akhmadeeva E., Kurashvili L., Sergeeva-Kondrachenko M., et al. Effect of Osteomed Forte on hormonal status and course of osteoporosis in postmenopausal women with androgen deficiency. Vrach [Physician]. 2015; (3): 28–32. (in Russian)

57. Ismailova O., Eremina N., Strukov V., Kirillova T., Posmetnaya T., Smirnova N. Treatment for chronic generalized periodontitis in postmenopausal women in terms of bone mineral density. Vrach [Physician]. 2015; (10): 56–8. (in Russian)

58. Lubenets A. Treatment of proximal femur injuries in older age group patients. Vrach [Physician]. 2017; (7): 64–7. (in Russian)

59. Strukov V., Elistratov D., Maksimov M., Shcherbakova Yu., Kuptsova T. Method of diagnosing osteoporosis and determining effectiveness of the medicine in the treatment of the disease. Farmatsiya [Pharmacy]. 2013; (8): 40–3. (in Russian)

60. Strukov V., Elistratov D., Kislov A., Eremin N., Ismailova O., Shcherbakova Yu., et al. Osteomed Forte – a new approach to the treatment of presenile and senile osteoporosis. Vrach [Physician]. 2013; (10): 39–41. (in Russian)

61. Strukov V., Zhivotoshchuk V., Kovalev A. How to increase the efficiency of the treatment of deforming osteoarthrosis of fingers and toes in elderly patients. Vrach [Physician]. 2014; (10): 49–50. (in Russian)

62. Strukov V., Kislov A., Elistratov D., Maksimova M., Shcherbakova Yu., Kuptsova T. Diagnostics and selecting the medicine for the treatment of postmenopausal osteoporosis. URL: https://osteomed.su/lechenie-osteoporoza-pocle-menopausy-osteomed-forte/ (in Russian)

63. Kokoreva I.G., Koren’kov A.V., Solov’ev I.A. Effect of Osteomed Forte on the terms of bone fracture consolidation in children and adolescents. Vrach [Physician]. 2020; (1): 82–5. (in Russian)

64. Iordanishvili A.K. Basics of dental arthrology. Saint-Petersburg: Chelovek, 2018: 176 p. (in Russian)

65.Bakken K., Fournier A., Lund E., et al. Menopausal hormone therapy and breast cancer risk: impact of different treatments. The European Prospective Investigation into Cancer and Nutrition. Int J Cancer. 2011; 128: 144–56.

66. Balan V.E., Andreeva E.N., Il’ina L.M. Hormone replacement therapy and breast cancer: scientific evidence and the reasons of baseless stable fear (a review). Problemy reproduktsii [Problems of Reproduction]. 2013; (4): 94–102. (in Russian)

67. Vinogradova Y., Coupland C., Hippisley-Cox J. Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases. BMJ. 2020; 371: m3873. DOI: https://doi.org/10.1136/bmj.m3873 URL: https://www.sciencedaily.com/releases/2020/10/201028195605.htm

68. Backe F., Takiishi T., Korf H., Gysemans C., Mathieu C. Vitamin D: Modulator of the immune system. Curr Opin Pharmacol. 2010; 10 (4): 482–96.

69. Chen S., Sims G.P., Chen X.X., Gu Y.Y., Chen S., Lipsky P.E. Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol. 2007; 179 (3): 1634–47.

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)

CHIEF EDITORS
CHIEF EDITOR
Sukhikh Gennadii Tikhonovich
Academician of the Russian Academy of Medical Sciences, V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Moscow
CHIEF EDITOR
Kurtser Mark Arkadievich
Academician of the Russian Academy of Sciences, MD, Professor, Head of the Obstetrics and Gynecology Subdepartment of the Pediatric Department, N.I. Pirogov Russian National Scientific Research Medical University, Ministry of Health of the Russian Federation
CHIEF EDITOR
Radzinsky Viktor Evseevich
Corresponding Member of the Russian Academy of Sciences, MD, Professor, Head of the Subdepartment of Obstetrics and Gynecology with a Course of Perinatology of the Medical Department in the Russian People?s Friendship University

Journals of «GEOTAR-Media»