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2 . 2022

Efficiency of embryo transfers in patients in frozen embryo transfer of in vitro fertilization

Abstract

Background. Infertility is an important public health problem. According to WHO, about 48 million couples and 186 million people worldwide suffer from infertility. The presence of sexually transmitted infections (STIs) is widely recognized as an etiological factor in infertility. In particular, persistent HPV infection has been found in infertile patients. Although there is now a safe and highly effective vaccine to prevent HPV infection, there are still no effective treatments to completely get rid of the virus. The question of the impact of HPV and HPV vaccination on the outcomes of ART programs, including frozen embryo transfer (FET), also remains unexplored.

Aim. To study the effectiveness of in vitro fertilization (IVF) programs with FET on the 5th day of development in patients with persistent HPV infection, without it and previously vaccinated.

Material and methods. We analyzed the results of 179 patients with infertility who applied for treatment in the ART program from 2019 to 2021. The patients were divided into three groups. 72 treatment cycles were performed using previously frozen blastocysts. The transfer was carried out in an induced cycle on the background of hormone replacement therapy.

Results. The pregnancy rate for embryo transfer is 2.2 times higher in patients of group 2 (73.9%) and 1.7 times higher in patients of group 3 (60.7%) in comparison to the group of HPV-positive patients (33, 3%). Nondeveloping pregnancy occurred only in the group of HPV-positive patients (4.8%). Predictors that reduce the likelihood of a positive result after FET has been established.

Conclusion. Persistent HPV infection has a negative impact on the outcomes of ART programs, and also reduces the frequency of pregnancy and increases the frequency of reproductive losses. Vaccination against HPV does not have a negative impact on the state of ovarian function, and it increases the frequency of pregnancy in FET.

Keywords:assisted reproductive technologies; in vitro fertilization; frozen embryo transfer; HPV infection; pregnancy rate; reproductive outcomes; HPV vaccination

Funding. Search and analytical work was carried out at the personal expense of the team of authors.

Conflict of interest. The authors of this article have confirmed that there is no conflict of interest to report.

Contribution. Review of publications, analysis of the data obtained, writing the text of the article - Bashankaeva Yu.N., Zarochen-tseva N.V., Krasnopolskaya K.V., Isakova K.M.

For citation: Bashankaeva Yu.N., Zarochentseva N.V., Krasnopolskaya K.V., Isakova K.M. Efficiency of embryo transfers in patients in frozen embryo transfer of in vitro fertilization. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie [Obstetrics and Gynecology: News, Opinions, Training]. 2022; 10 (1): 23-30. DOI: https://doi.org/10.33029/2303-9698-2022-10-2-23-30 (in Russian)

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CHIEF EDITORS
CHIEF EDITOR
Sukhikh Gennadii Tikhonovich
Academician of the Russian Academy of Medical Sciences, V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Moscow
CHIEF EDITOR
Kurtser Mark Arkadievich
Academician of the Russian Academy of Sciences, MD, Professor, Head of the Obstetrics and Gynecology Subdepartment of the Pediatric Department, N.I. Pirogov Russian National Scientific Research Medical University, Ministry of Health of the Russian Federation
CHIEF EDITOR
Radzinsky Viktor Evseevich
Corresponding Member of the Russian Academy of Sciences, MD, Professor, Head of the Subdepartment of Obstetrics and Gynecology with a Course of Perinatology of the Medical Department in the Russian People?s Friendship University

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