To the content
3. Приложение . 2021

The efficiency of a complex method for the treatment of uterine infertility

Abstract

Thin endometrial syndrome is associated with infertility and adverse reproductive outcomes, as well as with implantation failure and miscarriage. The high frequency of ineffective ART programs in patients with uterine infertility dictates the priority of finding new ways to solve this problem and the development of an integrated approach to the study of patients with uterine infertility. The article presents modern ideas about the causes, treatment tactics, consequences of the "thin" endometrial syndrome according to domestic and foreign literature, as well as the management of patients with uterine infertility.

Keywords:"thin" endometrium; infertility of uterine origin; physiotherapy; assisted reproductive technologies; in vitro fertilization

Funding. The authors received no financial support.

Conflict of interest. The authors declare no conflict of interest.

For citation: Orazov M.R., Krasnopolskaya K.V., Silantieva E.S., Lagutina E.V. The efficiency of a complex method for the treatment of uterine infertility. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie [Obstetrics and Gynecology: News, Opinions, Training]. 2021; 9 (3). Supplement: 93-7. DOI: https://doi.org/10.33029/2303-9698-2021-9-3suppl-93-97 (in Russian)

REFERENCES

1. Vander Borght M., Wyns C. Fertility and infertility: Definition and epidemiology. Clin Biochem. 2018; 62: 2-10.

2. Seshadri S., Morris G., Serhal P., Saab W. Assisted conception in women of advanced maternal age. Best Pract Res Clin Obstet Gynaecol. 2021; 70: 10-20.

3. Vitagliano A., Noventa M., Saccone G., et al. Endometrial scratch injury before intrauterine insemination: is it time to re-evaluate its value? Evidence from a systematic review and meta-analysis of randomized controlled trials. Fertil Steril. 2018; 109 (1): 84-96.

4. Vitagliano A., Saccardi C., Noventa M., et al. Does endometrial scratching really improve intrauterine insemination outcome? Injury timing can make a huge difference. J Gynecol Obstet Hum Reprod. 2018; 47 (1): 33-4.

5. Cozzolino M., Vitagliano A., Di Giovanni M.V., et al. Ultrasound-guided embryo transfer: summary of the evidence and new perspectives. A systematic review and meta-analysis. Reprod Biomed Online. 2018; 36 (5): 524-42.

6. Tersoglio A.E., Tersoglio S., Salatino D.R., et al. Regenerative therapy by endometrial mesenchymal stem cells in thin endometrium with repeated implantation failure. A novel strategy. JBRA Assist Reprod. 2020; 24 (2): 118-27.

7. Richter K.S., Bugge K.R., Bromer J.G., Levy M.J. Relationship between endometrial thickness and embryo implantation, based on 1294 cycles of in vitro fertilization with transfer of two blastocyst-stage embryos. Fertil Steril. 2007; 87: 53-9.

8. Li W., Cao Z., Yu X., Hu W. Effect of growth hormone on thin endometrium via intrauterine infusion. Ann Transl Med. 2021; 9 (16): 1325.

9. Kasius A., Smit J.G., Torrance H.L., et al. Endometrial thickness and pregnancy rates after IVF: a systematic review and meta-analysis. Hum Reprod Update. 2014; 20: 530-41.

10. Kovacs P., Matyas S., Boda K., et al. The effect of endometrial thickness on IVF/ICSI outcome. Hum Reprod. 2003; 18: 2337-41.

11. von Wolff M., Fah M., Roumet M., et al. Thin endometrium is also associated with lower clinical pregnancy rate in unstimulated menstrual cycles: a study based on natural cycle IVF. Front Endocrinol (Lausanne). 2018; 9: 776.

12. Mahajan N. Endometrial receptivity array: clinical application. J Hum Reprod Sci. 2015; 8 (3): 121-9.

13. Yuan X., Saravelos S.H., Wang Q., Xu Y., Li T.-C., Zhou C. Endometrial thickness as a predictor of pregnancy outcomes in 10787 fresh IVF-ICSI cycles. Reprod Biomed Online. 2016; 33 (2): 197-205.

14. Mouhayar Y., Franasiak J.M., Sharara F.I. Obstetrical complications of thin endometrium in assisted reproductive technologies: a systematic review. J Assist Re-prod Genet. 2019; 36 (4): 607-11.

15. Birzhanova G.T., Biktasheva Kh.M. Optimization of treatment of patients with thin endometrium. 2018. (in Russian)

16. Fang R., Cai L., Xiong F., et al. The effect of endometrial thickness on the day of hCG administration on pregnancy outcome in the first fresh IVF/ICSI cycle. Gynecol Endocrinol. 2016; 32 (6): 473-6.

17. Gaidarova A.Kh., Kulchitskaya D.B., Sycheva A.Yu., Alisultanova L.S., Kotenko N.V., Tarasova T.Yu. Dynamics of the functional characteristics of the microcirculation system in the women of late reproductive age presenting with chronic endometritis under effect of contrast massage. Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury. 2014; 91 (4): 33-37. (in Russian)

18. Du J., Lu H., Yu X., LG Z., Mi L., Zhang X. Efficacy and safety of platelet-rich plasma for the treatment of thin endometrium. 2020.

19. Khramtsova A.Yu., Bashmakova N.V. Global view on the problem of «thin» endometrium: solutions to the problem in assisted reproductive technology (literature review). Russian Journal of Human Reproduction. 2019; 25 (4): 69-76. (in Russian) Problemy reproduktsii [Problems of Reproduction]. 2019; 25 (4): 69-76. DOI: https://doi.org/10.17116/repro20192504169 (in Russian)

20. Urman B., Boza A., Balaban B. Platelet-rich plasma another add-on treatment getting out of hand? How can clinicians preserve the best interest of their patients? Hum Reprod. 2019; 34: 2099-103.

21. Tehraninejad E.S., Kashani N.G., Hosseini A., Tarafdari A. Autologous platelet-rich plasma infusion does not improve pregnancy outcomes in frozen embryo transfer cycles in women with history of repeated implantation failure without thin endometrium. J Obstet Gynaecol Res. 2021; 47 (1): 147-51.

22. Tersoglio A.E., Tersoglio S., Salatino D.R., Castro M., Gonzalez A., Hinojosa M., et al. Regenerative therapy by endometrial mesenchymal stem cells in thin endometrium with repeated implantation failure. A novel strategy. JBRA Assist Reprod. 2020; 24 (2): 118-27.

23. Martynov S.A. Possibilities of electrotherapy in the preparation of patients with chronic endometritis for ART programs: Autoabstr. of Diss. Moscow, 2005. (in Russian)

24. Ponomarenko G.N., Silant’eva E.S., Kondrina E.F. Physiotherapy in reproductive gynecology. Saint Petersburg: IITs VMA, 2008. (in Russian)

25. Shishkanova O.L. Optimization of tactics for the treatment of chronic endometritis in patients with impaired reproductive function using pulsed electrotherapy: Autoabstr. of Diss. Moscow, 2008. (in Russian)

26. Silantieva E.S. Physical methods of structural and functional remodeling of the endometrium in women with impaired reproductive function: Diss. Moscow, 2008. (in Russian)

27. Alieva K.U. Optimization of endometrial preparation in the IVF and PE program in patients with uterine hemodynamic disorders. Autoabstr. of Diss. Moscow, 2007. (in Russian)

28. Birzhanova G.T., Biktasheva Kh.M. Optimization of treatment of patients with thin endometrium. 2018.

29. Krasnopolskaya K.V., Ershova I.Yu. Thin endometrium. Moscow, 2021. P. 85.

30. Evaluation of implantation and clinical pregnancy rates after endometrial scratching in women with recurrent implantation failure. Ital J Gynaecol Obstet. 2018; 30 (2): 39-44.

31. Barash A., et al. Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization. Fertil Steril. 2003; 79 (6): 1317-22.

32. Simon C., Bellver J. Scratching beneath «The Scratching Case»: systematic reviews and meta-analyses, the back door for evidence-based medicine. Hum Reprod. 2014; 29 (8): 1618-21.

33. Nastri C.O., et al. Endometrial injury in women undergoing assisted reproductive techniques. Cochrane Database Syst. Rev. 2015; 7: CD009517.

34. Orazov M.R., Krasnopol’skaya K.V., Silant’eva E.S., et al. The efficacy of alternative treatment tactics for uterine infertility. Ginekologiya [Gynecology]. 2021; 23 (1): 92-6. DOI: https://doi.org/10.26442/20795696.2021.1.200672 (in Russian)

35. Orazov M.R., Krasnopol’skaya K.V., Silantyeva E.S., Mikhaleva L.M., Ershova I.Yu., Lagutina E.V., et al. «Problematic» endometrium as a factor of infertility: the search for ways to overcome it continues. Trudniy patsient [Difficult Patient]. 2020; 18 (8-9): 13-9. (in Russian)

36. Orazov M.R., Krasnopol’skaya K.V., Silant’eva E.S., Mikhaleva L.M., Lagutina E.V., Orekhov R.E., et al. A method for increasing endometrial receptivity in patients with uterine a form of infertility caused by endometrial dysfunction, in preparation for the in vitro fertilization (IVF) procedure according to the cryoprotocol. Russian patent 2021 according to IPC A61B17/425 A61N1/18. (in Russian)

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)

CHIEF EDITORS
CHIEF EDITOR
Sukhikh Gennadii Tikhonovich
Academician of the Russian Academy of Medical Sciences, V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Moscow
CHIEF EDITOR
Kurtser Mark Arkadievich
Academician of the Russian Academy of Sciences, MD, Professor, Head of the Obstetrics and Gynecology Subdepartment of the Pediatric Department, N.I. Pirogov Russian National Scientific Research Medical University, Ministry of Health of the Russian Federation
CHIEF EDITOR
Radzinsky Viktor Evseevich
Corresponding Member of the Russian Academy of Sciences, MD, Professor, Head of the Subdepartment of Obstetrics and Gynecology with a Course of Perinatology of the Medical Department in the Russian People?s Friendship University

Journals of «GEOTAR-Media»