Metabolic features of patients with missed miscarriage
AbstractThe aim of this study was to determine prognostic serological markers in patients with non-progressive pregnancy (NP).
Material and methods. In this study, 182 patients aged 18-45 years were examined, which were divided into 3 groups depending on the progression of pregnancy: Group I - 90 patients with non-developing pregnancy before the gestational age of 11 weeks at the time of the examination; Group II - 52 patients with spontaneous miscarriage before 11 weeks of gestation and Group III - 40 women with progressive uterine pregnancy before 11 weeks of gestation (control group). All women underwent liquid chromatography - a mass spectrometric method for studying blood serum with the determination of potentially significant serum markers.
Analysis of the results of the study showed a direct relationship between non-developing pregnancy and the presence of circulating potentially significant serological markers, such as APOC2 apolipoprotein in the blood serum of patients with NP.
Conclusion. The study revealed the possibility of using mass spectrometric analysis of blood serum to determine APOC2 as a prognostic marker in patients with NP.
Keywords:undeveloped pregnancy; serological markers; apolipoproteins; dyslipidemia; impared fat metabolism
Funding. The authors received no financial support.
Conflict of interest. The authors declare no conflict of interest.
For citation: Haddad Kh., Orazmuradov A.A., Morozov S.G., Akhmatova A.N., Lopatin A.M., Krylova Yu.V., Bekbaeva I.V., Suleyma-nova Zh.Z., Kyrtikov S.I., Ramazanova F.U. Metabolic features of patients with missed miscarriage. Akusherstvo i ginekologiya: no-vosti, mneniya, obuchenie [Obstetrics and Gynecology: News, Opinions, Training]. 2021; 9 (3). Supplement: 30-4. DOI: https://doi.org/10.33029/2303-9698-2021-9-3suppl-30-34 (in Russian)
REFERENCES
1. Early pregnancy. From preconception preparation to healthy gestation / ed. V.E. Radzinsky, A.A. Orazmuradov. Ch. 14. Non-developing pregnancy. Moscow, 2020: 509-537. (in Russian)
2. Orazmuradov A.A., Akhmatova A.N., Haddad Kh., Lopatin A.M., Bekbaeva I.V., Arakelyan G.A., et al. Predictive markers of missed miscarriage. Int J Biomed. 2021; 11 (1): 65-7. DOI: https://doi.org/10.21103/Article11(1)_ShC
3. Loskutova I.V., Bichevskaya R.G. Lipid spectrum of blood in pregnancy with habitual miscarriage an early times at chronic liver diseases. Sciences of Europe. 2017; 20-1 (20): 72-6. (in Russian)
4. Sergeevich G.A., et al. Association study of APOE, LPL AND NOS3 polymorphisms with the risk of common cardio pathology in children and pregnant women. Ekologicheskaya genetika [Ecological Genetics]. 2011; 9 (4): 25-34. (in Russian)
5. Korkmazer E., et al. Study on potential role of apolipoprotein E in recurrent pregnancy loss. Exp Ther Med. 2013; 5 (5): 1408-10.
6. Li J., et al. Apolipoprotein E (Apo E) gene polymorphisms and recurrent pregnancy loss: a meta-analysis. J Assist Reprod Genet. 2014; 31 (2): 139-48.
7. Asgari N., et al. Positive association of Apolipoprotein E4 polymorphism with recurrent pregnancy loss in Iranian patients. J Assist Reprod Genet. 2013; 30 (2): 265-8.
8. Svyatova G.S., Berezina G.M.,, Salimbaeva D.N., Kirikbayeva M.S., Murtaza-lieva A.V., Saduakasova K.Z. Genetic aspects of the idiopathic recurrent miscarriage. literature review. Nauka i zdravookhranenie [Science and Healthcare]. 2019; 21 (4): 37-49. (in Russian)
9. Wolska A., Dunbar R.L., Freeman L.A., Ueda M., Amar M.J., Sviridov D.O., et al. Apolipoprotein C-II: new findings related to genetics, biochemistry, and role in triglyceride metabolism. Atherosclerosis. 2017; 267: 49-60.