Endometriosis: a riddle of nature or an example of failure of science?
AbstractBackground. Endometriosis is a chronic gynecological disease, the etiology and pathogenesis of which are not fully known. The disease and its consequences are the greatest burden on health care and society, for each individual patient and her family. Unlike, for example, diabetes mellitus (DM) and cardiovascular diseases (CVD), endometriosis, which causes no less harm to the state and society, primarily due to its association with infertility, is not recognized as a socially significant disease, which determines the corresponding state policy and investment in research.
The key question: why is endometriosis, known to science for more than 300 years, is still "a disease of riddles and assumptions"?
Short answer: perhaps, due to underestimation of its social significance by government agencies and the lack of the required volume of investments in science, which indirectly reflects the publication activity in refereed databases.
Aim of the study - to compare the worldwide publication activity in relation to endometriosis and such socially significant diseases as diabetes mellitus and diseases of the cardiovascular system.
Material and methods. The material for the study was articles on endometriosis, diabetes mellitus, and CVD, published in the period 2009-2020 and posted in the search engine Pubmed.gov. Using the methods of descriptive and comparative statistics, an analysis of the frequency of publication of articles and their annual growth over the past 12 years was carried out.
Results. The analysis showed a significantly lower publication activity in relation to endometriosis compared with diabetes and CVD (p<0.001).
Conclusion. Endometriosis is a "disease of mystery and speculation," but it is partly an example of the failure of modern science. Gaps in the modern paradigm of its etiology and pathogenesis today, in the era of globalization, are undoubtedly interconnected with a significantly lower publication activity in comparison with such socially significant diseases as diabetes and CVD. It is possible that with a change in the attitude of government agencies and the emergence of national programs to combat endometriosis, which will inevitably lead to an increase in the number of publications in refereed databases, scientists will be able to find out the true causes and mechanisms of this disease, and clinicians and healthcare organizers - to develop effective management of endometriosis and stop calling it "the disease of riddles and assumptions."
Keywords:endometriosis; diabetes mellitus; cardiovascular disease
Funding. The authors received no financial support.
Conflict of interest. The authors declare no conflict of interest.
For citation: Volkova S.V., Khamoshina M.B., Orazov M.R., Soyunov M.A. Endometriosis: a riddle of nature or an example of failure of science. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie [Obstetrics and Gynecology: News, Opinions, Training]. 2021; 9 (3). Supplement: 24-9. DOI: https://doi.org/10.33029/2303-9698-2021-9-3suppl-24-29 (in Russian)
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