Labor induction in full-term pregnancy. Cervidil - intravaginal therapeutic system with dinoprostone

• Olga K. Doronina

Abstract

The problem of programmed labor is very multifaceted and for many decades the interest of researchers around the world in this problem has only increased.

The aim of the article was to study modern strategies for effective cervical preparation using vaginal prostaglandin E₂, since correctly performed pre-induction is the basis for successful programmed labor.

An analysis and review of 38 literature sources devoted to various aspects of problems of induced labor (increasing frequency of their usage worldwide, labor induction methods, key success factors, central role of prostaglandins in preparing for labour, cervical ripening and in childbirth) was carried out.

Particular attention has been paid to Cervidil intravaginal therapeutic system usage which is containing 10 mg of controlled-release dinoprostone for cervical preparation. Advantages of this form of dinoprostone administration, as well as new directions for researches, that may expanding already existing instruction of prostaglandin E₂ vaginal usage and can demonstrate their effectiveness are indicated.

Keywords:unripe cervix, pre-induction, cervical preparation, labor induction, prostaglandins, dinoprostone, Cervidil

References

1. Obstetric aggression v.2.0 / ed. by V.E. Radzinsky. Moscow: Status-Praesents magazine, 2017. 872 p. (in Russian)

2. Obstetrics: national guidance/ ed. byG.M.Savelyeva, G.T.Sukhikh,V.N. Serov, V.E. Radzinsky. 2^nd ed. Moscow: GEOTAR-Media, 2020. 1088 p. (in Russian)

3. Obstetrics: textbook / ed. by V.E. Radzinsky, A.M. Fuchs. Moscow: GEOTAR-Media, 2020. 1056 p. (in Russian)

4. Obstetrics. A guide to practical exercises: a textbook / ed. by V.E. Radzinsky, I.N. Kostin. 6^th ed. Moscow: GEOTAR-Media, 2021. 736 p. (in Russian)

5. Chen W., Xue J., Peprah M.K., et al. A systematic review and network meta-analysis comparing the use of Foley bulbs, misoprostol, and dinoprostone for cervical ripening in the induction of labor. BJOG. 2016; 123 (3): 346-54.

6. Ravanos K., Dagklis T., Petousis S., et al. Factors implicated in the initiation of human parturition in term and preterm labor: a review. Gynecol Endocrinol. 2015; 31 (9): 679-83.

7. Hamilton B.E., Martin J.A., Osterman M.J., et al. Births: final data for 2014. Natl Vital Stat Rep. 2015; 64 (12): 1-64.

8. Alfirevic Z., Keeney E., Dowswell T., et al. Methods to induce labour: a systematic review, network meta-analysis and cost-effectiveness analysis. BJOG. 2016; 123 (9): 1462-70. DOI: https://doi.org/10.1111/1471-0528.13981

9. Vannuccini S., Bocchi C., Severi F.M. et al. Endocrinology of human parturition. Ann Endocrinol. 2016; 77 (2): 105-13.

10. Levine L.D., Downes K.L., Elovitz M.A., et al. Mechanical and pharmacologic methods of labor induction: a randomized controlled trial. Obstet Gynecol. 2016; 128: 1357-64.

11. Levine L.D., Valencia C.M., Tolosa J.E. Induction of labor in continuing pregnancies. Best Pract Res Clin Obstet Gynecol. 2020; 67: 90-9.

12. Rozenberg P., Chevret S., Ville Y. Comparison of pre-induction ultrasonographic cervical length and Bishop score in predicting risk of cesarean section after labor induction with prostaglandins. Gynecol Obstet Fertil. 2005; 33 (1-2): 17-22.

13. Coste Mazeau P., Hessas M., Martin R., et al. Is there an interest in repeating the vaginal administration of dinoprostone (Propess^®), to promote induction of labor of pregnant women at term? (REDINO): study protocol for a randomized controlled trial. Trials. 2020; 21: 51. DOI: https://doi.org/10.1186/s13063-019-3985-0

14. Dubourdeau A.L., Berdin A., Mangin M., Ramanah R., Maillet R., Riethmuller D. Obesity and primiparity: Risky delivery? J Gynecol Obstet Biol Reprod (Paris). 2015; 44 (8): 699-705.

15. Gauthier T., Mazeau S., Dalmay F., et al. Obesity and cervical ripening failure risk. J Matern Fetal Neonatal Med. 2012; 25 (3): 304-7.

16. Goetzl L. Methods of cervical ripening and labor induction: pharmacologic. Clin Obstet Gynecol. 2014; 57 (2): 377-90.

17. Alfirevic Z., Keeney E., Dowswell T., et al. Labour induction with prostaglandins: a systematic review and network meta-analysis. BMJ. 2015; 350: h217.

18. Jozwiak M., Oude Rengerink K., Ten Eikelder M.L.G., et al. Foley catheter or prostaglandin E2 inserts for induction of labour at term: an open-label randomized controlled trial (PROBAAT-P trial) and systematic review of literature. Eur J Obstet Gynecol Reprod Biol. 2013; 170: 137-45.

19. Eser A., Ozkaya E., Abide C.Y., et al. Transcervical Foley balloon catheter and vaginal prostaglandin E2 insert combination vs. vaginal prostaglandin E2 insert only for induction of labor at term: a randomized clinical trial. Arch Gynecol Obstet. 2019; 299: 451-7.

20. Konopka C.K., Glanzner W.G., Rigo M.L., et al. Responsivity to PGE2 labor induction involves concomitant differential prostaglandin E receptor gene expression in cervix and myometrium. Genet Mol Res. 2015; 14 (3): 10 877-87.

21. Mosher A.A., Rainey K.J., Giembycz M.A., et al. Prostaglandin E2 represses interleukin 1 beta-induced inflammatory mediator output from pregnant human myometrial cells through the EP2 and EP4 receptors. Biol Reprod. 2012; 87 (1): 1-10.

22. Unlugedik E., Alfaidy N., Holloway A., et al. Expression and regulation of prostaglandin receptors in the human placenta and fetal membranes at term and preterm. Reprod Fertil Dev. 2010; 22 (5): 796-807.

23. Sugimoto Y., Inazumi T., Tsuchiya S. Roles of prostaglandin receptors in female reproduction. J Biochem. 2015; 157 (2): 73-8.

24. Bakker R., Pierce S., Myers D. The role of prostaglandins E1 and E2, dinoprostone, and misoprostol in cervical ripening and the induction of labor: a mechanistic approach. Arch Gynecol Obstet. 2017; 296: 167-79.

25. Yount S.M., Lassiter N. The pharmacology of prostaglandins for induction of labor. J Midwifery Womens Health. 2013; 58 (2): 133-44.

26. Wing D.A., Sheibani L. Pharmacotherapy options for labor induction. Expert Opin Pharmacother. 2015; 16 (11): 1657-68.

27. Pharmaceuticals Ferring Cervidil_® [prescribing information]. Par-sippany: Ferring Pharmaceuticals, 2016.

28. Hiersch L., Borovich A., Gabbay-Benziv R., et al. Can we predict successful cervical ripening with prostaglandin E2 vaginal inserts? Arch Gynecol Obstet. 2017; 295: 343-9.

29. Ducarme G., Chesnoy V., Petit L. Factors predicting unsuccessful labor induction with dinoprostone in post-term pregnancy with unfavorable cervix. J Gynecol Obstet Biol Reprod (Paris). 2015; 44 (1): 28-33.

30. Lesage S., Mercier F.J. Parturiente agee (podcast). Prat En Anesth Reanim. 2014; 18 (3): 164-9.

31. Antonazzo P., Laoreti A., Personeni C., et al. Vaginal dinoprostone versus intravenous oxytocin for labor induction in patients not responsive to a first dose of dinoprostone: a randomized prospective study. Reprod Sci. 2016; 23 (6): 779-84.

32. Ashwal E., Hiersch L., Melamed N., et al. Pre-induction cervical ripening: comparing between two vaginal preparations of dinoprostone in women with an unfavorable cervix. J Matern Fetal Neonatal Med. 2014; 27 (18): 1874-79.

33. Ducarme G., Chesnoy V., Petit L. Factors predicting unsuccessful labor induction with dinoprostone in post-term pregnancy with unfavorable cervix. J Gynecol Obstet Biol Reprod (Paris). 2015; 44: 28-33.

34. Hernandez-Martfnez A., Pascual-Pedreno A.I., Bano-Garnes A.B., et al. Predictive model for risk of cesarean section in pregnant women after induction of labor. Arch Gynecol Obstet. 2016; 293: 529-38.

35. Du C., Liu Y., Liu Y., et al. Double-balloon catheter vs dinoprostone vaginal insert for induction of labor with an unfavorable cervix. Arch. Gynecol. Obstet. 2015; 291: 1221-7.

36. Beckwith L., Magner K., Kritzer S., et al. Prostaglandin versus mechanical dilation and the effect of maternal obesity on failure to achieve active labor: a cohort study. J Matern Fetal Neonatal Med. 2017; 30 (13): 1621-25. DOI: https://doi.org/10.1080/14767058.2016.1220523

37. Agarwal P., Greene D.G., Sherman S., et al. Structural characterization and developability assessment of sustained release hydrogels for rapid implementation during preclinical studies. Eur J Pharm Sci. 2021; 158: 105689. DOI: https://doi.org/10.1016/j.ejps.2020.105689

38. World Health Organization. WHO recommendations for induction of labour. Geneva : WHO, 2011.

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)