To the content
2 . 2021

Fetal growth restriction: causes and risk factors

Abstract

This paper addresses the main issues regarding the impact of fetal growth restriction on the subsequent child's and adult's lives as well as the causes of this pathology, maternal and fetal factors and the role of infection. The incidence of Acute Respiratory Viral Infections (ARVI), including influenza and COVID-19, in pregnant women and the effect of these infections on the pregnancy course and the fetus and newborn health are assessed. The results of effective treatment of vaginal infections and herpes simplex by combined interferon-based medicines Vagiferon® and Herpferon® are presented. This article also highlights the importance of ARVI nonspecific prevention and treatment in pregnant women with the use of the intranasal recombinant interferon alpha-2b medicine Grippferon®, which helps to reduce the frequency of pregnancy complications and perinatal pathology.

Keywords:pregnancy, fetal growth restriction, risk factors, prevention, interferon-based medicines, Vagiferon, Herpferon, Grippferon

Funding. The authors received no financial support.

Conflict of interest. The authors declare no conflict of interest.

Contribution. Research concept and design - Posiseeva L.V.; collection and processing of materials - Posiseeva L.V., Kiseleva O.Yu., GLik M.V.; text writing - Posiseeva L.V., Kiseleva O.Yu.

For citation: Posiseeva L.V., Kiseleva O.Yu., Glik M.V. Fetal growth restriction: causes and risk factorsAkusherstvo i ginekologiya: novosti, mneniya, obuchenie [Obstetrics and Gynecology: News, Opinions, Training]. 2021; 9 (2): 92-9. DOI: https://doi.org/10.33029/2303-9698-2021-9-2-92-99 (in Russian)

References

1. Makarov I.O., Yudina E.V., Borovkova E.I. Fetal growth retardation. Moscow: MEDpress-inform, 2012: 56 p. (in Russian)

2. Dan'kova I.V., Melkozerova O.A., Goncharova S.V. Ovarian reserve in adolescent girls born with intrauterine growth retardation. Voprosy ginekologii, akusherstva i perinatologii [Problems of Gynecology, Obstetrics and Perinatology]. 2015; 14 (3): 39-43. (in Russian)

3. Khuraseva A.B. Features of the perimenopausal period in women, depending on the birth weight. RMZH Mat' i ditya [RMJ. Mother and Child]. 2018; 1 (1): 40-3. DOI: http://doi:10.32364/2618-8430-2018-1-1-40-43 (in Russian)

4. Khuraseva A.B., Kuznetsova I.V. Interrelation of body weight at birth with the risk of cardiovascular pathology and the possibility of cardiovascular prophylaxis. Meditsinskiy alfavit [Medical Alphabet]. 2019; 4 [33 (408)]: 15-30. DOI: http://doi:10.33667/2078-5631-2019-4-33(408)-25-30 (in Russian)

5. Min Mu, Song Ye, Ming-Jie Bai, Guo-Li Liu, Yuan Tong, Su-Fang Wang, et al. Birth weight and subsequent risk of asthma: a systematic review and meta-analysis. Heart Lung Circ. 2014; 23 (6): 511-9. DOI: http://doi:10.1016/j.hlc.2013.11.018

6. Saleem T., Sajjad N., Fatima S., Habib N., Ali S.R., Qadir M. Intrauterine growth retardation - small events, big consequences. Ital J Pediatr. 2011; 37: 41. DOI: https://doi.org/10.1186/1824-7288-37-41

7. Thorn S.R., Rozance P.J., Brown L.D., Hay W.W. Jr. The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes. Semin Reprod Med. 2011; 29 (3): 225-36. DOI: http://dok10.1055/s-0031-1275516

8. Marciniak A., Patro-Matysza J., Kimber-Trojnar Z., Marciniak B., Oleszczuk J., Leszczynska-Gorzelak B. Fetal programming of the metabolic syndrome. Taiwan J Obstet Gynecol. 2017; 56 (2): 133-8. DOI: http://doi:10.1016/j.tjog.2017.01.001

9. Belousova T.V., Andryushina I.V. Fetal growth retardation and its impact on health. Modern approaches to feeding children. Lechashchiy vrach [Attending Physician]. 2018; (9): 50-9. (in Russian)

10. Nagaeva E.V., Shiryaeva T.Yu. «Intrauterine programming» of hormonal and metabolic processes and intrauterine growth retardation syndrome. Problemy endokrinologii [Problems of Endocrinology]. 2010; 56 (6): 32-40. (in Russian)

11. The main indicators of maternal and child health, the activities of the child protection and obstetric services in the Russian Federation. Moscow, 2018. (in Russian)

12. Peretyatko L.P., Kulida L.V., Protsenko E.V. Morphology of extremely low birth weight fetuses and newborns. Ivanovo: Ivanovo, 2005: 384 p. (in Russian)

13. Goryunova A.G., Simonova M.S., Murashko A.V. Fetal growth retardation syndrome and placental adaptation. Arkhiv akusherstva i ginekologii imeni V.F. Snegireva [Archive of Obstetrics and Gynecology named after V.F. Snegirev]. 2016; 3 (2): 76-80. http://doi:10.18821/2313-8726-2016-3-2-76-80 (in Russian)

14. Logvinova I.I., Emel'yanova A.S. Risk factors for the birth of low birth weight children, the structure of morbidity, mortality. Rossiyskiy pediatricheskiy zhurnal [Russian Journal of Pediatrics]. 2000; (4): 50-4. (in Russian)

15. Budyukhina O.A. Fetal growth retardation syndrome - a modern view of the problem (literature review). Problemy zdorov'ya i ekologii [Problems of Health and Ecology]. 2009; 1 (19): 84-9. (in Russian)

16. Kulakov V.I., Ordzhonikidze N.V., Tyutyunik V.A. Placental insufficiency and infection. Moscow, 2004: 494 p. (in Russian)

17. Ul'yanina E.V., Akhmadeev N.R., Khayrullina G.R. Pathology of the placenta with fetal growth retardation - echographic and morphological signs of a critical condition. Kazanskiy meditsinskiy zhurnal [Kazan Medical Journal]. 2016; 97 (6): 869-72. DOI: http://doi:10.3817750/KMJ2016-869 (in Russian)

18. Kuznetsov R.A., Peretyatko L.P., Rachkova O.V. Morphological criteria for primary placental insufficiency. Vestnik RUDN. Seriya: Meditsina. Akusherstvo i ginekologiya [Bulletin of the Russian University of Peoples' Friendship. Series: Medicine. Obstetrics and Gynecology]. 2011; (5): 34-9. (in Russian)

19. Posiseeva L.V., Tulupova M.S., Khamoshina M.B. Male factor of miscarriage: a look at the problem. Doktor Ru. Endokrinologiya. Chast' II [Doctor Ru. Endocrinology. Part II]. 2013; 7-2 (85): 56-60. (in Russian)

20. Timokhina E.V. Pathogenetic mechanisms of development of fetal growth retardation syndrome and treatment problems. Voprosy ginekologii, akusherstva i perinatologii [Problems of Gynecology, Obstetrics and Perinatology]. 2012; 11 (2): 17-20. (in Russian)

21. Kudryashova A.V., Sotnikova N.Yu., Posiseeva L.V., Panova I.A., Vedeneeva M.V. The role of the immune system in the formation of intrauterine growth retardation of the fetus. Ivanovo: Ivanovo, 2009: 240 p. (in Russian)

22. Sotnikova N.Yu., Vedeneeva M.V., Posiseeva L.V., Kudryashova A.B. Gene regulation of immune apoptosis in peripheral blood in fetal growth retardation syndrome. Meditsinskaya immunologiya [Medical Immunology]. 2005; 7 (2-3): 191. (in Russian)

23. Avrutskaya V.V. Dynamics of interleukin production in women with complicated pregnancy. Rossiyskiy vestnik akushera-ginecologa [Russian Bulletin of Obstetrician-Gynecologist]. 2008; (3): 45-8. (in Russian)

24. Frolova M.V., Sotnikova N.Yu. Features of the functional activity of peripheral B-lymphocytes in women during pregnancy complicated by fetal growth retardation. Vestnik Ivanovskoy meditsinskoy akademii [Bulletin of the Ivanovo Medical Academy]. 2016; 21 (4): 15-9. (in Russian)

25. Posiseeva L.V., Nazarov S.B., Tatarinov Yu.S. Proteins of the human reproductive system in obstetrics and gynecology. Ivanovo: Ivanovo, 2006: 240 p. (in Russian)

26. Lanir N., Aharon A., Brenner B. Haemostatic mechanisms in human placenta. Best Pract Res Clin Haematol. 2003; 16 (2): 183-95.

27. Raev M.B., Litvinova L.S., Yurova K.A., Dunets N.A., Khaziakhmatova O.G., Timganova V.P., et al. The role of trophoblastic b1-glycoprotein in the regulation of the cytokine and chemokine profiles of intact mononuclear cells. Doklady Akademii nauk [Reports of the Academy of Sciences]. 2017; 475 (3): 349-52. DOI: http://dok10.7868/S0869565217210253 (in Russian)

28. Zamorina S.A., Raev M.B. Study of the immunomodulatory effects of human trophoblastic [31-glycoprotein. Fiziologiya cheloveka [Human Physiology]. 2015; 41 (1): 117-23. DOI: http://doi:10.7868/S0131164615010142 (in Russian)

29. Malevich Yu.K., Shostak Yu.K. Placental insufficiency. Minsk: Belarus', 2007: 157 p. (in Russian)

30. Budyukhina O.A. Fetal growth retardation syndrome - a modern view of the problem (literature review). Problemy zdorov'ya i ekologii [Problems of Health and Ecology]. 2009; 1 (19): 83-9. (in Russian)

31. Posiseeva L.V., Peretyatko L.P., Kulida L.V., Khamoshina M.B. Placental factors of stillbirth: prevention options. Rossiyskiy vestnik akushera-ginecologa [Russian Bulletin of Obstetrician-Gynecologist]. 2014; 14 (5): 83-6. (in Russian)

32. Subbotina Yu.A., Timofeev V.P., Nechaev V.V., Aleksandrova M.V. The value of opportunistic microflora in the course of pregnancy, childbirth and the initial level of health of young children: an information letter for the heads of the Central State Sanitary and Epidemiological Service, institutions of medical and preventive care for mothers and children, hygienists, epidemiologists, family doctors, interns, medical students. Saint Petersburg, 2000: 7 p. (in Russian)

33. Posiseeva L.V., Panova I.A., Sotnikova N.Yu., Kudryashova A.V., Lukina N.S. Early prognostic criteria for the nature of pregnancy in women with markers of urogenital infection. Akusherstvo i ginekologiya [Obstetrics and Gynecology]. 2009; (2): 23-7. (in Russian)

34. Organization of medical care for pregnant women, women in labor, parturient women and newborns with a new coronavirus infection COVID-19: guidelines of the Ministry of Health of the Russian Federation. Moscow, 2020: 55 p. (in Russian)

35. Guidelines for outpatient care in obstetrics and gynecology. In: V.E. Radzinsky (ed.). 2nd ed., rev. and add. Moscow: GEOTAR-Media, 2014: 944 p. (in Russian)

36. Kovalev E.V., Zan'ko Yu.V., Trubkina T.Yu. Risk factors for fetal growth retardation associated with the health and lifestyle of a pregnant woman. Mat' i ditya v Kuzbasse [Mother and Child in Kuzbass]. 2014; 4 (59): 24-8. (in Russian)

37. Obstetrics: National guidance. In: G.M. Savel'eva, G.T. Sukhikh, V.N. Serov, V.E. Radzinsky (eds). Moscow: GEOTAR-Media, 2016: 393-400. (in Russian)

38. Kiselev O.I. Immunosuppression in pregnancy and influenza. Voprosy virusologii [Problems of Virology]. 2012; 57 (6): 5-8. (in Russian)

39. Kolobukhina L.V., L'vov D.K., Burtseva E.I. Medical virology. Moscow: MIA, 2008: 176-182. (in Russian)

40. Kravchenko E.N., Kuklina L.V. Obstetric and perinatal outcomes in pregnant women during the acute respiratory viral infections epidemic. The efficacy of prevention. Voprosy ginekologii, akusherstva i perinatologii [Problems of Gynecology, Obstetrics and Perinatology]. 2018; 4 (17): 92-6. DOI: http://doi:10.20953/1726-1678-2018-4-92-96 (in Russian)

41. Belokrinitskaya T.E., Artymuk N.V., Filippov O.S., Shifman E.M. Features of the course of COVID-19 in pregnant women in the Far East and Siberia. Problemy reproduktsii [Problems of Reproduction]. 2020; 26 (3): 85-91. DOI: http://doi:10.17116/repro20202603185105 (in Russian)

42. Jafari M., Pormohammad A., Sheikh Neshin S.A., Ghorbani S., Bose D., Alimohammadi S., et al. Clinical characteristics and outcomes of pregnant women with COVID-19 and comparison with control patients: a systematic review and meta-analysis. Rev Med Virol. 2021; Jan 2: e2208. DOI: http://dok10.1002/rmv.2208 PMID: 33387448.

43. Diriba K., Awulachew E., Getu E. The effect of coronavirus infection (SARS-CoV-2, MERS-CoV, and SARS-CoV) during pregnancy and the possibility of vertical maternal-fetal transmission: a systematic review and meta-analysis. Eur J Med Res. 2020; 25 (1): 39. DOI: http://doi:10.1186/s40001-020-00439-w

44. Bezhenar V.F., Zazerskaya I.E., Bettikher O.A., Nesterov I.M., Bautin A.E. Controversial issues of obstetric tactics in the management of pregnancy and delivery of patients with the new coronavirus infection COVID-19. Akusherstvo i ginekologiya [Obstetrics and Gynecology]. 2020; (5): 13-21. DOI: http://doi:10.18565/aig.2020.5.13-21 (in Russian)

45. Lu-Culligan A., Chavan A.R., Vijayakumar P., Irshaid L., Cour-chaine E.M., Milano K.M., et al. Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with robust inflammatory response at the maternal-fetal interface. Medicine. 2021. Epub 2012 April 22. DOI: http://doi:10.1016/j.medj.2021.04.016

46. Pregravid preparation: clinical protocol. In V.E. Radzinsky, et al. (author-developer). Moscow: Redaktsiya zhurnala StatusPraesens, 2016: 80 p. (in Russian)

47. Arestova I.M., Kiseleva N.I., Zhukova N.P., Deykalo N.S. Diagnosis, treatment and prevention of certain infections specific to the perinatal period. Features of preparation for pregnancy. Okhrana materinstva i detstva [Protection of Motherhood and Childhood]. 2015; 1 (25): 41-51. (in Russian)

48. Immunotherapy: A guide for physicians. In: R.M. Khaitov, R.I. Ataullakhanov (eds). Moscow: GEOTAR-Media, 2018: 768 p. (in Russian)

49. Rogozhina I.E., Stolyarova U.V., Neyfel'd I.V. Optimization of the treatment of cervical pathology in women with recurrent nonspecific cervicitis and vaginitis. Farmateka [Pharmateca]. 2017; 3 (336): 31-5. (in Russian)

50. Kravchenko E.N. Immunocorrective therapy in the complex treatment of nonspecific bacterial vaginitis. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie [Obstetrics and Gynecology: News, Opinions, Training]. 2015; 1 (7): 49-53. (in Russian)

51. Olina A.A., Meteleva T.A. Modern possibilities of therapy for patients with nonspecific infectious diseases of the vagina. Rossiyskiy vestnik akushera-ginecologa [Russian Bulletin of Obstetrician-Gynecologist]. 2016; 16 (6): 89-94. DOI: http://doi:10.17116/rosakush201616689-94 (in Russian)

52. Boyko E.L., Malyshkina A.I., Vasil'eva T.P., Kovaleva A.V. Vagiferon in the treatment of bacterial vaginosis and bacterial-viral mixed infection in non-pregnant women. Effektivnaya farmakoterapiya. Akusherstvo i ginekol-ogya [Effective Pharmacotherapy. Obstetrics and Gynecology]. 2012; (5): 22-5. (in Russian)

53. Metelkina S.A., Averina D.M., Kuptsova L.V., Gur'ev D.L. Experience of use of the combined medication Vagiferon® for topical application in the treatment of bacterial vaginosis. Zhurnal akusherstva i zhenskikh bolezney [Journal of Obstetrics and Women's Diseases]. 2015; 64 (4): 95-8. (in Russian)

54. Aminodova I.P., Posiseeva L.V. The effectiveness of Vagiferon in the treatment of non-pregnant women with acute vaginitis and concomitant cervicitis. Remedium. Konsilium. Akusherstvo i ginekologiya [Remedium. Consilium. Obstetrics and Gynecology ]. 2017; 3 (153): 22. (in Russian)

55. Koryagina M.S., Posiseeva L.V. Herpferon: experience with herpesvirus infection. Effektivnaya farmakoterapiya. Dermatovenerologiya i dermatokosmetologiya. [Effective Pharmacotherapy. Dermatovenerology and Dermatocosmetology] 2015; 2 (33): 14-6. (in Russian)

56. Gaponyuk P.Ya., Doroshenko E.M. The role of the Russian medication Grippferon in the treatment and prevention of influenza and other acute respiratory viral infections. Poliklinika [Policlinic]. 2008; (5): 22-6. (in Russian)

57. Yushchuk N.D., Khadartsev O.S. The use of interferons in the prevention and treatment of respiratory viral infections in adults and children. Lechashchiy vrach [Attending Physician]. 2018; (3): 67-72. (in Russian)

58. Krasnov V.V. The efficacy of recombinant interferon-alpha in the treatment and prevention of ARVI. Voprosy prakticheskoy pediatrii [Problems of Practical Pediatrics]. 2016; 11 (4): 44-52. DOI: http://doi:10.20953/1817-7646-2016-4-44-52 (in Russian)

59. Burtseva E.I., Mukasheva E.A., Rosatkevich A.G. Main directions of effective influenza prevention in modern conditions. Epidemiologiya i vaktsinoprofilaktika [Epidemiology and Vaccine Prophylaxis]. 2017; 16 [5 (96)]: 80-6. (in Russian)

60. Nadey E.V., Nesterova K.I., Nechayeva G.I., Shupina M.I., Tereshchenko Yu.V. The place of topical interferons in the treatment of acute respiratory viral infection in pregnant women. Rossiyskiy allergologicheskiy zhurnal [Russian Allergological Journal]. 2017; 14 (1): 109-10. (in Russian)

61. Priputnevich T.V., Achkasova E.N., Chubarov V.V., Gordeev A.B. Acute respiratory diseases and influenza in modern obstetrics: epidemiological features and problems of diagnosis: a review of the literature. Epi-demiologiya i vaktsinoprofilaktika [Epidemiology and Vaccine Prophylaxis]. 2019; 18 (3): 89-97. DOI: http://doi.org/10.31631/2073-3046-2019-18-3-89-97 (in Russian)

62. Bashmakova N.V., Chistyakova G.N., Pavlichenko M.V., Remizova I.I., Plyusnina N.N., Bychkova S.V. Clinical and immunological neonatal period characteristics of newborns, whose mothers experienced ARVI and influenza in the third trimester of pregnancy. Voprosy ginekologii, akusherstva i perinatologii [Problems of Gynecology, Obstetrics and Perinatology]. 2017; 16 (3): 14-23. DOI: http://doi.10.20953/1726-1678-2017-3-14-23 (in Russian)

63. On the prevention and treatment of influenza and pneumonia in pregnant women: Information letter of the Ministry of Health of the Russian Federation of 12.28.2016. Moscow Publ. 2016: 13 p. (in Russian)

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)

CHIEF EDITORS
CHIEF EDITOR
Sukhikh Gennadii Tikhonovich
Academician of the Russian Academy of Medical Sciences, V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Moscow
CHIEF EDITOR
Kurtser Mark Arkadievich
Academician of the Russian Academy of Sciences, MD, Professor, Head of the Obstetrics and Gynecology Subdepartment of the Pediatric Department, N.I. Pirogov Russian National Scientific Research Medical University, Ministry of Health of the Russian Federation
CHIEF EDITOR
Radzinsky Viktor Evseevich
Corresponding Member of the Russian Academy of Sciences, MD, Professor, Head of the Subdepartment of Obstetrics and Gynecology with a Course of Perinatology of the Medical Department in the Russian People?s Friendship University

Journals of «GEOTAR-Media»