Role of pregravid training in improving perinatal outcomes in HIV-infected women
AbstractThe aim of our cohort study is to assess levels of viral load, hemoglobin, platelets, immune status, vaginal microbiota and urine seeding, birth outcomes depending on absence or presence of pregravid training.
Material and methods. 90 women of reproductive age with stage 3 and 4A of HIV infection participated. To compare the groups, the Kraskel—Wallis, Mann-Whitney criteria were used. It was found that in women without pregravid training, the total bacterial mass of lactobacilli (p=0.004) is higher than the bacterial mass of staphylococci and streptococci (p=0.009); higher total amount of seeded microorganisms (p=0.004) at the background of high viral load (p=0.001); often the cause of asymptomatic bacteriuria is Enteroccocus faecalis with a viral load above the detection threshold (p=0.009).
Results. Pregravid training contributes to an increase in the level of hemoglobin in women (p=0.038), a decrease in the viral load in pregnancy (p=0.01), reduces the risk of preterm birth (p=0.04), contributes to normal birth weight (p=0.023); partner viral load is associated with female viral Load and risk of preterm birth (p=0.000). Thus, we show that the availability of pregravid training in HIV-infected women, including with a partner, contributes to favorable perinatal outcomes.
Keywords:vaginal microbiota, HIV infection, pregravidic training, asymptomatic bacteriuria, viral load, anemia, immune status
Funding. The authors received no financiaL support.
Conflict of interest. The authors decLare no conflict of interest.
For citation: Ovchinnikova A.O., MikhaLchenko S.V., Baranov I.I. RoLe of pregravid training in improving perinataL outcomes in HIV-infected women. Akusherstvo i ginekoLogiya: novosti, mneniya, obuchenie [Obstetrics and GynecoLogy: News, Opinions, Training]. 2021; 9 (2): 6-12. DOI: https://doi.org/10.33029/2303-9698-2021-9-2-6-12 (in Russian)
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