The evolution of diagnostic and therapeutic approaches in premature ovarian failure

• Tabeeva G.I.
• A.A. Pozdnyakova
• L.A. Marchenko

Abstract

Premature ovarian failure (POF) – pathological condition characterized by amenorrhea, infertility, symptoms of hypoestrogyny on the background of increased levels of gonadotropins (FSH, LH) in women under 40 years. Genetic, infectious-toxic, autoimmune and iatrogenic causes can contribute to the depletion of ovarian reserve. This pathology is characterized by the development of secondary ovarian amenorrhea in combination with clinical manifestations of the deficit of sex hormones. POF is a risk factor reducing the quality of the bone and increase the risk of osteoporosis and cardiovascular pathology. This disease is associated with autoimmune endocrine and non-endocrine diseases, and among them the most often presented in autoimmune thyroiditis (more than 20% of patients) with initial or subclinical disease. To fill the deficit of sex hormones in the POF is the most rational to apply traditional hormone replacement therapy in cyclic mode. The innovative method for the treatment of this category of patients is based on the use of dehydroepiandrosterone (DHEA).

Keywords:premature ovarian failure, hormone replacement therapy, deficit of sex hormones dehydroepiandrosterone

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