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2 . 2020

Cytomegalovirus infection in pregnant women and newborns: epidemiological analysis, new approaches to diagnosis and treatment

Abstract

We studied the incidence of cytomegalovirus (CMV) infection from 2008-2018 in different categories of patients based on the official health statistics, as well as incidence and lethality in patients with congenital CMV (cCMV). We identified a huge discrepancy in the number of officially reported cases of CMV infection in pregnancy and cCMV compared with the actual figures. The frequency of CMV detection, diagnostic and prognostic values of laboratory markers of acute primary and non-primary active CMV in pregnancy and cCMV are presented. The presence of CMV DNA in maternal Leukocytes was proved to be a risk factor of infection transmission to the fetus. Moreover, we present the analysis of the available treatment options of maternal and fetal infection and discuss the benefits of valganciclovir and CMV immunoglobulins therapy in both primary and non-primary maternal CMV infection and cCMV in infants.

Keywords:active CMV, pregnancy, valganciclovir, Neocytotect

Funding. The study had no sponsor support.

Conflict of interests. The authors declare no conflict of interests.

For citation: Shakhgildyan V.I., Alexandrova E.P., Kozyrina N.V., Shipulina O.Yu., Domonova E.A., Shakhgildian N.V. Cytomegalovirus infection in pregnant women and newborns: epidemiological analysis, new approaches to diagnosis and treatment. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie [Obstetrics and Gynecology: News, Opinions, Training]. 2020; 8 (2): С. 80-94. DOI: 10.24411/2303-9698-2020-12008 (in Russian)

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CHIEF EDITORS
CHIEF EDITOR
Sukhikh Gennadii Tikhonovich
Academician of the Russian Academy of Medical Sciences, V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Moscow
CHIEF EDITOR
Kurtser Mark Arkadievich
Academician of the Russian Academy of Sciences, MD, Professor, Head of the Obstetrics and Gynecology Subdepartment of the Pediatric Department, N.I. Pirogov Russian National Scientific Research Medical University, Ministry of Health of the Russian Federation
CHIEF EDITOR
Radzinsky Viktor Evseevich
Corresponding Member of the Russian Academy of Sciences, MD, Professor, Head of the Subdepartment of Obstetrics and Gynecology with a Course of Perinatology of the Medical Department in the Russian People?s Friendship University

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