Acute vaginitis of mixed etiology: a modern approach to treatment

• Malova Irina O.
• Afanasyeva Irina G.
• Gusevskaya Ksenia A.

Abstract

Aim of the study - to analyze the etiological factors and the frequency of their detection in mixed vaginitis in women of reproductive age. To study the effectiveness of the treatment of mixed vaginitis with combination preparation for topical administration containing ornidazole, neomycin, econazole, prednisolone.

Material and methods. Analysis of outpatient cards of 293 women of reproductive age for 2014-2019 has been carried out for study of the etiological factors of mixed vaginitis. Survey, treatment and control of cure in 60 patients with mixed vaginitis were held for study of the effectiveness of local treatment of mixed vaginitis with a combination preparation containing ornidazole, econazole, neomycin and prednisolone. The examination included clinical, microscopic, molecular biological methods.

Results. It has been established that in recent years, the frequency of detection of aerobic microorganisms (50.3% of patients), ureaplasma (58.4%), herpes simplex viruses (19.1%) increased with vaginitis. Candida spp. (55.5% of patients), anaerobic bacteria (41.0%) and T. vaginalis (39.9%) traditionally constitute a significant proportion of the etiological composition of mixed vaginitis. The results of treatment of acute mixed vaginitis in 60 women with a combined preparation for local treatment, including ornidazole, neomycin, econazole, prednisolone, have been studied. Clinical and laboratory efficacy was 95.0%.

Conclusion. In the etiology of mixed vaginitis conditionally pathogenic microorganisms (Candida spp., aerobic and anaerobic bacteria) prevail over unconditional pathogens (T. vaginalis and HSV): the ratio was 2.7: 1. A variety of combinations of microorganisms responsible for the development of vaginitis dictate the need for the appointment of multi-component therapy. The high clinical and laboratory efficacy of the combined preparation, containing ornidazole, neomycin, econazole and prednisolone, and its good tolerability allow us to recommend the drug for the treatment of mixed vaginitis, in particular, as an ambulance for acute illness.

Keywords:vaginitis, aerobic, anaerobic, Candida spp., T vaginalis, aerobic vaginitis, non-specific vaginitis, Trichomonas vaginitis, bacterial vaginosis, candidial vaginitis, ornidazole, neomycin, econazole, prednisolone

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