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3 . 2019

Prolonged mode of contraception in young women - a new clinician tool

Abstract

Protecting reproductive health of young women is a priority guideline for solution medical and demographic problems of the Russian Federation. An effective tool for increasing the reproductive potential of prospective mothers is hormonal contraception. Modern Combined Oral Contraceptives (COCs), which are also used for therapeutic purposes, evidentiary allow to prevent unintended pregnancy and abortion, to reduce the prevalence of many gynecological disorders and somatic diseases, as well as individual perinatal risk. Drug selection is determined integrally, taking into account woman's age, fertility plans, health status, personal acceptability and availability of the method, demand for non-contraceptive effects realization, as well as necessity for pregravid preparation or treatment of diseases listed in the prescribing information, which is usually associated with the formula. An additional parameter for COCs selection is receiving mode. Outside of already established "21+7", "24+4" and "26+2" receiving modes, a micro-dosed COCs with prolonged "84+7" regimen has been authorized to be marketed in Russia. It can be a drug of choice for women suffering from epilepsy, diabetes mellitus, anemia, endometriosis, polycystic ovarian syndrome, uterine fibroid, chronic abnormal uterine bleedings. COCs supplementation in a prolonged mode allows to provide safely high contraceptive reliability and reversible contraception in healthy young women.

Keywords:COCs, contraception, young women, reproductive health, safety

For citation: Khamoshina M.B., Chakchurina I.A., Dmitrieva E.M., Abitova M.Z., Orazmuradova A.A. Prolonged mode of contraception in young women - a new clinician tool. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie [Obstetrics and Gynecology: News, Opinions, Training]. 2019; 7 (3): 102-6. doi: 10.24411/2303-9698-2019-13015. (in Russian)

References

1. Health care in Russia. 2017: statistical compilation. Rosstat. Moscow, 2017. 170 р. (in Russian)

2. Tulupova M.S., Chotchayeva A.I., Khamoshina M.B., Kaygorodova L.A., Nesvyacheny L.A., Streltsova V.L. Regional features of health of the pregnant women living in the Karachaevo-Circassian Republic and Primorsky Krai. Vestnik RUDN [Bulletin of Russian Peoples' Friendship University]. Seriya Meditsina. Akusherstvo i ginekologiya. Series Medicine. Obstetrics and gynecology. 2012; 6: 78-85. (in Russian)

3. Kroll R., Reape K.Z., Margolis M. The efficacy and safety of a low-dose, 91-day, extended-regimen oral contraceptive with continuous ethinyl estradiol. Contraception. 2010; 81 (1): 41-8.

4. URL: http://www.gks.ru .

5. The concept of demographic development of the Russian Federation for the period until 2025.URL: https://rosmintrud.ru/ministry/pro-gramms/6 . (in Russian)

6. Barnhart K., Mirkin S., Grubb G., Constantine G. Return to fertility after cessation of a continuous oral contraceptive. Fertil Steril. 2009; 91: 1654-6.

7. ACOG Practice Bulletin No. 110: noncontraceptive uses of hormonal contraceptives. Obstet Gynecol. 2010; 115 (1): 206-18.

8. Lebedeva M.G., Khamoshina M.B., Vostrikova T.V., Litchak N.V., Arkhipova M.P. Evolution of the Reproductive Health in Teenage Girls: Medical and Geographic Aspects Doctor.Ru. Gynecology. Endocrinology. 2012; 7 (75): 35-41. (in Russian)

9. Khamoshina M.B. Reproductive health depository: young women. Ways of forming rational prerequisites for the regulation of fertility: a methodological guide. Edit. by V.E. Radzinsky. Moscow: StatusPraesens, 2013. 48 р. (in Russian)

10. Khamoshina M.B. Results of the observational study EVA PLUS: Use of combined oral contraceptives with f olate in real clinical practice in Russia. Akusherstvo i ginekologiya [Obstetrics and Gynecology]. 2019; 3: 114-20. (in Russian)

11. Radzinskiy V.E., Khamoshina M.B. Unsolved Problems in Modern Gynecology: Quo vadis? Doctor.Ru. Gynecology. Endocrinology. 2016; 7 (124): 4-9.

12. Radzinsky V.E., Khamoshina M.B., Makletsova S.A. Optimization of the medical choice of hormonal contraception as a way to preserve women's health at the population level. StatusPraesens. 2016; 1 (30): 20-8. (in Russian)

13. Anderson F.D., Gibbons W., Portman D. Safety and efficacy of an extended-regimen oral contraceptive utilizing continuous low-dose ethinyl estradiol. Contraception. 2006; 73 (3): 229-34.

14. Khamoshina M.B., Savelyeva I.S., Zorina E.A., Tulupova M.S., Zulumyan T.N. Postabortal rehabilitation - aspects of the problem: possibilities of combined oral contraceptivesGinekologiya [Gynecology]. 2013; 15 (1): 60-3. (in Russian)

15. Radzinsky V.E., Khamoshina M.B. Tools for choosing hormonal contraception: counseling, algorithm, mobile application. StatusPraesens. 2016; 3 (32): 130-5. (in Russian)

16. Khamoshina M.B., Raevskaya O.A. Freedom of choice. Justification of the safety of the new prolonged regimen of COC administration [84 + 7]. StatusPraesens. 2017; 3 (39): 39-48. (in Russian)

17. Edelman A., Micks E., Gallo M.F., et al. Continuous or extended cycle vs cyclic use of combined hormonal contraceptives for contraception. Cochrane Database Syst Rev. 2014; 7: CD004695.

18. URL: http://www.demoscope.ru/weekly/ssp/rus_nac_26.php .

19. Radzinskiy V.E., Khamoshina M.B., Arkhipova M.P., Lichak N.V. Reproductive health of adolescents in Russia: statistics, problems and prospects of improvement. Gynecol Endocrinol. 2014; 30 (S1): 2-5. (in Russian)

20. Radzinsky V.E., Khamoshina M.B. Algorithm for choosing a contraceptive method. Contraception counseling as a basis for personified choice: a newsletter. Moscow: StatusPraesens. 2017. 20 p. (in Russian)

21. Khamoshina M.B., Raevskaya O.A., Simonovskaya Kh.Yu. Prolonged intake of COCs as a new tool for the work of an obstetrician-gynecologist. A new dosage regimen for COCs (84 + 7) in the practice of an obstetrician-gynecologist. Work with prejudices and objections: newsletter. Edit. by V.E. Radzinsky. Moscow: StatusPraesens, 2017. 24 p. (in Russian)

22. Yurev V.K., Mirskiy V.E. The reproductive potential of students from st. petersburg. Sovremennyy problemy nauki i obrazovaniya [Modern Problems of Science and Education]. 2015; 3. URL: http://science-educa-tion.ru/ru/article/view?id=18119 . (date of access: 25.06.2019) (in Russian)

23. Archer D.F. Menstrual-cycle-related symptoms: a review of the rationale for continuous use of oral contraceptives. Contraception. 2006; 74 (5): 359-66.

24. Coffee A.L., Sulak P.J., Hill A.J., et al. Extended cycle combined oral contraceptives and prophylactic frovatriptan during the hormone-free interval in women with menstrual-related migraines. J Womens Health (Larchmt). 2014; 23 (4): 310-7.

25. Medical Eligibility Criteria for Contraceptive Use. 5th ed. Geneva: World Health Organization, 2015.

26. Guideline: Daily Iron Supplementation in Adult Women and Adolescent Girls. Geneva: World Health Organization, 2016. URL: https://apps.who.int .

27. Toxqui L., Perez-Granados A.M., Blanco-Rojo R., et al. A simple and feasible questionnaire to estimate menstrual blood loss: relationship with hematological and gynecological parameters in young women. BMC Womens Health. 2014; 14: 71.

28. Instructions for the use of the medicinal product for medical use Modell Libera. URL: http://www.grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid . (in Russian)

29. Davis A.R., Kroll R., Soltes B., et al. The occurrence of menses or pregnancy after cessation of a continuous oral contraceptive. Fertil Steril. 2008; 89: 1059-63.

30. Sitruk-Ware R. New progestagens for contraceptive use. Hum Re-prod Update. 2006; 12: 169-78.

31. Arkhipova M.P., Khamoshina M.B., Lebedeva M.G. et al. Reproductive and professional-production reserve of Russia in the mirror of official statistics. Abstracts of the VII All-Russian seminar “Reproductive Potential of Russia: Versions and Contraverses” (September 6-9, 2014, Sochi). Moscow: StatusPraesens, 2014: 5-6. (in Russian)

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CHIEF EDITORS
CHIEF EDITOR
Sukhikh Gennadii Tikhonovich
Academician of the Russian Academy of Medical Sciences, V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Moscow
CHIEF EDITOR
Kurtser Mark Arkadievich
Academician of the Russian Academy of Sciences, MD, Professor, Head of the Obstetrics and Gynecology Subdepartment of the Pediatric Department, N.I. Pirogov Russian National Scientific Research Medical University, Ministry of Health of the Russian Federation
CHIEF EDITOR
Radzinsky Viktor Evseevich
Corresponding Member of the Russian Academy of Sciences, MD, Professor, Head of the Subdepartment of Obstetrics and Gynecology with a Course of Perinatology of the Medical Department in the Russian People?s Friendship University

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