To the content
2 . 2019

Experience of applying the new combination drug for the treatment of urogenital of infections

Abstract

This article assesses the effectiveness of the use of the combined drug, antimicrobial, antifungal and anti-inflammatory effects for the treatment of vaginal infections. It has been shown that the early use of the drug of the last generation has minimal risk of bacterial resistance, wide spectrum of action and high efficacy in vaginal threads of any etiology.

Keywords:bacterial vaginosis, genital candidiasis, aerobic vaginitis

For citation: Sokolova T.M., Marinkin I.O., Kuleshov V.M., Makarov K.Yu. Experience of applying the new combination drug for the treatment of urogenital of infections. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie [Obstetrics and Gynecology: News, Opinions, Training]. 2019; 7 (2): 68-72. doi: 10.24411/2303-9698-2019-12009. (in Russian)

References

1. Nardis C., Mosca L., Mastromarino P. Vaginal microbiota and viral sexually transmitted diseases. Ann Ig. 2013; 25 (5): 443-56.

2. Liu M.B., Xu S.R., He Y., et al. Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis. PLoS One. 2013; 8 (11): 79-81.

3. Jahic M., Mulavdic M., Nurkic J., et al. Clinical characteristics of aerobic vaginitis and its association to vaginal candidiasis, trichomonas vaginitis and bacterial vaginosis. Med Arch. 2013; 67 (6): 428-30.

4. Sobel J.D., et al. Mixed vaginitis - more than coinfection and with therapeutic implications. Curr Infect Dis Rep. 2013; 15: 104-8.

5. Swidsinski A., Verstraelen H., Loening-Baucke V. Presence of a polymicrobial endometrial biofilm in patients with bacterial vaginosis. PLoS One. 2013; 8: 53-9.

6. Robertson S.R., McLean R.J.C. Beneficial biofilms. AIMS Bioeng. 2015; 2 (4): 437-48.

7. Cremer J., Melbinger A., Frey E. Growth dynamics and the evolution of cooperation in microbial populations. Sci Rep. 2012; 2: 281-3.

8. Petrova M.I., Lievens E., Malik S., et al. Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health. Front Physiol. 2015; 6: 81-4.

9. Van de Wijgert J.H., Borgdorff H., Verhelst R. The vaginal microbiota: what have we learned after a decade of molecular characterization? PLoS One. 2014; 9 (8): 105-9.

10. Rakhmatulina M.R., Nechayeva I.A. Biofilms of microorganisms and their role for the formation of resistance to anti-bacterial drugs. Vestnik dermatologii i venerologii [Journal of Dermatology and Venereology]. 2015; 60 (2): 58-62. (in Russian)

11. Macklaim J.M., Fernandes A.D., Di Bella J.M., Hammond J.A., et al. Comparative meta-RNA-seq of the vaginal microbiota and differential expression by Lactobacillus iners in health and dysbiosis. Microbiome. 2013; 1 (1): 12-4.

12. Sobel J.D., Reichman O., Misra D., Yoo W. Prognosis and treatment of desquamative inflammatory vaginitis. Obstet Gynecol. 2011; 117: 850-5.

13. Bibbo M., Wilbur D. Comprehensive cytopathology. London: Elsevier Health Sciences, 2014; 6: 88-9.

14. Radzinsky V.E., Ordiyants I.M. Two-stage therapy for vaginal infections. StatusPraesens. 2012; (5): 16. (in Russian)

15. Radzinsky V.E., Ordiyants I.M. The study of BIOS: a comparative evaluation of various treatment regimens for bacterial vaginosis and nonspecific vulvovaginitis. StatusPraesens. 2013; 1 (12): 52-5. (in Russian)

16. Sexually Transmitted Diseases Treatment Guidelines, 2015: Recommendations and Reports. CDC, 2015: 138 р.

17. Bebneva T.N., Dobretsova T.A. Mixed vaginal infections: a new ideology. Nonspecific vaginal infections in the practice of an obstetrician-gynecologist. Newsletter. In: V.E. Radzinsky, A.M. Savicheva (eds). Moscow, 2016: 24 р. (in Russian)

18. Swidsinski A., Loening-Baucke V., Mendling W., Dorffel Y., et al. Infection through structured polymicrobial Gardnerella biofilms (StPM-GB). Histol Histopathol. 2014; 29 (5): 567-87.

19. Breshears L.M., Edwards V.L., Ravel J., Peterson M.L. Lactobacillus crispatus inhibits growth of Gardnerella vaginalis and Neisseria gonorrhoeae on a porcine vaginal mucosa model. BMC Microbiol. 2015; 15 (1): 276.

20. Fofanova I.Yu., Prilepskaya V.N. Rational approaches to the treatment of bacterial vaginosis. Ginekologiya [Gynecology]. 2013; 15 (5): 2831. (in Russian)

21. Savicheva A.M., Rybina E.V., Ipastova I.D. bacterial vaginosis and mixed vaginal infections: is it possible to have one without the other? StatusPraesens. 2014; (23): 39-46. (in Russian)

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)

CHIEF EDITORS
CHIEF EDITOR
Sukhikh Gennadii Tikhonovich
Academician of the Russian Academy of Medical Sciences, V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Moscow
CHIEF EDITOR
Kurtser Mark Arkadievich
Academician of the Russian Academy of Sciences, MD, Professor, Head of the Obstetrics and Gynecology Subdepartment of the Pediatric Department, N.I. Pirogov Russian National Scientific Research Medical University, Ministry of Health of the Russian Federation
CHIEF EDITOR
Radzinsky Viktor Evseevich
Corresponding Member of the Russian Academy of Sciences, MD, Professor, Head of the Subdepartment of Obstetrics and Gynecology with a Course of Perinatology of the Medical Department in the Russian People?s Friendship University

Journals of «GEOTAR-Media»