Menopausal symptoms and sleep disorders in women: possibilities of alternative therapy

• Kuznetsova Irina V.

Abstract

The aim of the study was to analyze the literature data on the problem of pathogenesis and alternative therapy of sleep disorders and symptoms that occur in women during the menopausal transition and in postmenopausal women.

Material and methods. With the purpose of analysis implementation, research for foreign and domestic publications in the international citation system Pubmed, published over the past 15 years was made.

Results. The concepts of origin and reciprocal influences of menopausal symptoms and sleep disorders in women in menopause are summarized; data from studies in which effectiveness of menopausal symptoms and sleep disorders treatment with help of melatonin, phytoestrogens and micronutrients was investigated are systematized. Relevance of alternative medications combined application for adequate effect not only on vasomotor symptoms of menopausal syndrome, but also in relation to other problems associated with aging is noted.

Conclusion. Sleep disorders in menopausal transition and postmenopausal periods are only partially dependent on estrogen deficiency. Necessity for their correction is a result from quality of life considerable reduction, redoubling of other menopausal disorders and an increase in cardiometabolic risk in women with sleep disorders.

Keywords:menopause, vasomotor symptoms, sleep disorders, alternative therapy, melatonin, soy isoflavones, magnesium, vitamins

References

1. Harlow S.D., Gass M., Hall J.E., et al. Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging. J Clin Endocrinol Metab. 2012; 97: 1159-68.

2. Gold E.B., Crawford S.L., Avis N.E., et al. Factors related to age at natural menopause: longitudinal analyses from SWAN. Am J Epidemiol. 2013; 178: 70-83.

3. Schoenaker D.A., Jackson C.A., Rowlands J.V., Mishra G.D. Socioeconomic position, lifestyle factors and age at natural menopause: a systematic review and meta-analyses of studies across six continents. Int J Epidemiol. 2014; 43: 1542-62.

4. Сметник В.П. Менопаузальная гормонотерапия и сохранение здоровья женщин зрелого возраста // Климактерий. 2014. № 4. С. 8. [Smetnik V.P. Menopausal hormone therapy and preservation of the health of women of mature age. Klimakteriy [Menopause]. 2014; 4: 8. (in Russian)]

5. Qiu C., Chen H., Wen J., et al. Associations between age at men-arche and menopause with cardiovascular disease, diabetes, and osteoporosis in Chinese women. J Clin Endocrinol Metab. 2013; 98: 1612-21.

6. Ziv-Gal A., Gallicchio L., Miller S.R., Zacur H.A., Jodi A., Flaws J.A. Genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway as potential risk factors of menopausal hot flashes. Am J Obstet Gynecol. 2012; 207(3): 202.e9-202.e18.

7. Skurnick J.H., Weiss G., Goldsmith L.T., Santoro N., Crawford S. Longitudinal changes in hypothalamic and ovarian function in perimenopausal women with anovulatory cycles: relationship with vasomotor symptoms. Fertil Steril. 2009; 91 (4): 1127-34.

8. Ziv-Gal A., Flaws J.A. Factors that may influence the experience of hot flushes by healthy middle-aged women. J Womens Health (Larchmt). 2010; 19 (10): 1905-14.

9. Konings G., Brentjens L., Delvoux B., et al. Intracrine Regulation of Estrogen and Other Sex Steroid Levels in Endometrium and Non-gynecological Tissues; Pathology, Physiology, and Drug Discovery. Front Pharmacol. 2018; 9: 940.

10. Kravitz H.M., Joffe H. Sleep during the perimenopause: a SWAN story. Obstet Gynecol Clin North Am. 2011; 38: 567-86.

11. Полуэктов М.Г. Инсомния и расстройства дыхания во сне: возможности коррекции // Рус. мед. журн. 2011. Т. 19, № 15. [Poluektov M.G. Insomnia and sleep disorders in sleep: possibilities of correction. Russkiy meditsinskiy zhurnal [Russian Medical Journal]. 2011; 19 (15). (in Russian)]

12. Toffoletto S., Lanzenberger R., Gingnell M., Sundstrom-Poromaa I., Comasco E. Emotional and cognitive functional imaging of estrogen and progesterone effects in the female human brain: a systematic review. Psychoneuroendocrinology, 2014; 50: 28-52.

13. Abdulnour J., Doucet E., Brochu M., et al. The effect of the menopausal transition on body composition and cardiometabolic risk factors: a Montreal-Ottawa New Emerging Team group study. Menopause. 2012; 19: 760-7.

14. Fonken LK, Workman Jl, Walton JC, et al. Light and night increases body mass by shifting the time of food intake. Proc Natl Acad Sci USA. 2010; 107: 18664-9.

15. Pan A., Lucas M., Sun Q., et al. Biderectional assotiation between depression and type 2 diabetes mellitus in women. Arch Intern Med. 2010; 170: 1884-91.

16. Ho S.C., Wu S., Chan S.G., Sham A. Menopausal transition and changes of body composition: a prospective study in Chinese perimenopausal women. Int J Obes (Lond). 2010; 34: 1265-74.

17. Stubbins R.E., Najjar K., Holcomb V.B., Hong J., Nunez N.P. Oestrogen alters adipocyte biology and protects female mice from adipocyte inflammation and insulin resistance. Diabetes Obes Metab. 2012; 14: 58-66.

18. Simpson L., McArdle N., Eastwood P.R., et al. Physical Inactivity Is Associated with Moderate-Severe Obstructive Sleep Apnea. J Clin Sleep Med. 2015; 11: 1091-9.

19. Wietlisbach V., Marques-Vidal P., Kuulasmaa K., Karvanen J., Paccaud F. The relation of body mass index and abdominal adiposity with dyslipidemia in 27 general populations of the WHO MONICA Project. Nutr Metab Cardiovasc Dis 2013; 23: 432-42.

20. Roger V.L., Go A.S., Lloyd-Jones D.M., et а!. Heart Disease and Stroke Statistics-2012 Update: A Report From the American Heart Association. Circulation. 2012; 125 (1): e2-e220.

21. Mosca L., Benjamin E.J., Berra K., et al. Effectiveness-Based Guidelines for the Prevention of Cardiovascular Disease in Women-2011 Update: A Guideline From the American Heart Association. Circulation. 2011; 123 (11): 1243-62.

22. Lee M., Saver J.L., Chang B., Chang K.-H., et al. Presence of baseline prehypertension and risk of incident stroke. A metaanalysis. Neurology, 2011; 77: 1330-7.

23. Agrinier N., Cournot M., Dallongeville J., Arveiler D., Ducimetiere P., Ruidavets J.B., et al. Menopause and modifiable coronary heart disease risk factors: a population based study. Maturitas. 2010; 65 (3): 237-43.

24. Patel S.M., Ratcliffe S.J., Reilly M.P., et al. Higher serum testosterone concentration in older women is associated with insulin resistance, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab. 2009; 94 (12): 4776-84.

25. Baber R.J., Panay N., Fenton A., and the IMS Writing Group. Recommendations on women's midlife health and menopause hormone therapy. Climacteric. 2016: 19: 109-50.

26. Khosla S. Update on estrogens and the skeleton. J Clin Endocrinol Metab. 2010; 95: 3569-77.

27. Cintron D., Lipford M., Larrea-Mantilla L., et al. Efficacy of menopausal hormone therapy on sleep quality: systematic review and meta-analysis. Endocrine. 2017; 55: 702-11.

28. Cardini F., Lesi G., Lombardo F., van der Sluijs C, MSCG - Menopause Survey Collaborative Group. The use of complementary and alternative medicine by women experiencing menopausal symptoms in Bologna. BMC Womens Health. 2010; 10: 7.

29. Feng Q., O'Malley B.W. Nuclear Receptor Modulation - Role of Coregulators in Selective Estrogen Receptor Modulator (SERM) Actions. Steroids. 2014; 90: 39-43.

30. Martinkovich S., Shah D., Lobo Planey S., Arnott J.A. Selective estrogen receptor modulators: tissue specificity and clinical utility. Clin Interv Aging. 2014; 9: 1437-52.

31. Maximov Ph.Y., Lee T.M., Jordan V.C. The Discovery and Development of Selective Estrogen Receptor Modulators (SERMs) for Clinical Practice. Curr Clin Pharmacol. 2013; 8 (2): 135-55.

32. Lethaby A., Marjoribanks J., Kronrnberg F., Roberts H., Eden J., Brown J. Phytoestrogens for menopausal vasomotor symptoms. Cohrane Menstrual Disorders and Subfertility Group. Cohrane Database Syst Rev 2013; 12:CD001395.

33. Shakeri F., Taavoni S., Goushegir A., Haghani H. Effectiveness of red clover in alleviating menopausal symptoms: a 12-week randomized, controlled trial. Climacteric. 2015; 18: 568-73.

34. .Evans M., Elliott J.G., Sharma P., Berman R., Guthrie N. The effect of synthetic genistein on menopause symptom management in healthy postmenopausal women: a multi-center, randomized, placebo-controlled study. Maturitas. 2011; 68: 189-96.

35. Imhof M., Gocan A., Imhof M., Schmidt M. Soy germ extract alleviates menopausal hot flushes: placebo-controlled double-blind trial. Eur J Clin Nutr. 2018; 72 (7): 961-70.

36. Henderson V.W., John J.A., Hodis N.H., et al. Long-term soy isofla-vone supplementation and cognition in women: A randomized, controlled trial. Neurology 2012; 78: 1828-1841.

37. Rada G., Capurro D., Pantoja T., et al. Non-hormonal interventions for hot flashes in women with a history of breast cancer. Cochrane Database Syst Rev. 2010; (9): CD004923.

38. Beer A.-M., Neff A. Differentiated Evaluation of Extract-Specific Evidence on Cimicifuga racemosa's Efficacy and Safety for Climacteric Complaints. Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine 2013, Article ID 860602, 21 p.

39. Czuczwar P., Paszkowski T., Lisiecki M., Wozniak S., Stqpniak A. The safety and tolerance of phytotherapies in menopausal medicine -a review of the literature. Prz Menopauzalny. 2017; 16 (1): 8-11.

40. Joffe H., Petrillo L., Viguera A., et al. Eszopiclone improves insomnia and depressive and anxious symptoms in perimenopausal and postmenopausal women with hot flashes: a randomized, double-blinded, placebo-controlled crossover trial. Am J Obstet Gynecol. 2010; 202 (2): 171, e1- e171, e11.

41. Joffe H., Massler A., Sharkey K.M. Evaluation and Management of Sleep Disturbance During the Menopause Transition. Semin Reprod Med. 2010; 28 (5): 404-21.

42. Бурчаков Д.И. Доксиламин и мелатонин в коррекции нарушений сна в гинекологической практике // Журн. неврол. и психиатр. им. С.С. Корсакова. 2018. Т. 188, № 4. С. 67-72. [ Burchakov D.I. Doxyl-amine and melatonin in the correction of sleep disorders in gynecological practice Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [The Korsakov's Journal of Neurology and Psychiatry]. 118 (4): 67-72. (in Russian)]

43. Rudolph L.M., Bentley G.E., Calandra R.S., Paredes A.H., Tesone M., Wu T.J., Micevych P.E. Peripheral and Central Mechanisms Involved in the Hor- monal Control of Male and Female Reproduction. J Neuroendo-crinol. 2016; 28: 1-12.

44. Toffol E., Kalleinen N., Haukka J., Vakkuri O., Partonen T., Polo-Kantola P. The Effect of Hormone Therapy on Serum Melatonin Concentrations in Premenopausal and Postmenopausal Women: A Randomized, Double-blind, Placebo-controlled Study. Maturitas. 2014; 77.(4): 361-9.

45. Jehan S., Jean-Louis G., Zizi F., et al. Sleep, Melatonin, and the Menopausal Transition: What Are the Links? Sleep Sci. 2017; 10: 11-8.

46. Мадаева И.М., Семенова Н.В., Данусевич И.Н., Колесникова Л.И. Климактерический синдром, расстройства сна и мелатонин // Эффективная фармакотерапия. 2016. № 19. С. 86-92. [Madaeva I.M., Semenova N.V., Danusevich I.N., Kolesnikova L.I. Menopausal syndrome, sleep disorders and melatonin. Effektivnaya farmakoterapiya [Effective Pharmacotherapy]. 2016; 19: 86-92. (in Russian)]

47. Chojnacki C., Walecka-Kapica E., Klupinska G., Pawlowicz M., Blonska A., Chojnacki J. Effects of fluoxetine and melatonin on mood, sleep quality and body mass index in postmenopausal women. J Physiol Pharmacol. 2015; 66: 665-71.

48. Amstrup A.K., Sikjaer T., Pedersen S.B., HeickendorffL., Mosekilde L., Rejnmark L. Reduced fat mass and increased lean mass in response to 1 year of melatonin treatment in postmenopausal women: A randomized placebo- controlled trial. Clin Endocrinol. 2016; 84: 342-7.

49. Rondanelli M., Opizzi A., Monteferrario F., et al. The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: a double-blind, placebo-controlled clinical trial. J Am Geriatr Soc. 2011; 59 (1): 82-90.

50. Adami S., Giannini S., Bianchi G., Sinigaglia L., Di Munno O., Fiore C.E., Minisola S., Rossini M. Vitamin D status and response to treatment in postmenopausal osteoporosis. Osteoporos Int. 2009; 20: 239-44.

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