Modern view on etiology and pathogenesis of pre-malignant conditions and vulvar cancer

• Babaeva Nataliya A.
• Ashrafyan Lev A.
• Antonova Irina B.
• Aleshikova Olga I.
• Ivashina Svetlana V.
• Igor I. Baranov

Abstract

Vulvar cancer is a relatively rare disease among malignant tumors of female genital organs. Epidemiology of vulvar cancer has not been studied enough in our country. The risk group for its occurrence includes patients with dystrophic processes (lichen sclerosis) and vulvar dystrophy of varying degrees. Our studies have demonstrated key role of estrogen metabolites and viral infection ratio distortion in pathogenesis of dystrophic processes and vulvar cancer.

Keywords:vulvar cancer, lichen sclerosis, vulvar dystrophy

References

1. Urmancheeva A.F. Epidemiology of vulvar cancer. Risk and Forecast Factors Prakticheskaya onkologiya [Practical Oncology]. 2006; 7 (4): 189-96. (in Russian)

2. Grigoryan O.R. Modern principles of metabolic syndrome correction in postmenopausal women. Consilium Medicum. 2005; 7 (9): 45-7. (in Russian)

3. Cherenkov V.G., Aleksandrova I.V., Shpenkova A.A. Vulvar cancer: pathogenetic variants, diagnosis, treatment, plastic surgery. Opukholi zhenskoy reproduktivnoy sistemy [Tumors of Female Reproductive System]. 2010; (4): 78-83. (in Russian)

4. Bershteyn L.M. Hormones of adipose tissue (adipocytokines) ontogenetic and oncological aspect of the problem. Uspekhi gerontologii [Advances in Gerontology]. 2005; (16): 51-64. (in Russian)

5. Butrova S.A. Metabolic syndrome: pathogenesis, clinical presentation, diagnosis, treatment approaches. Russkiy meditsinskiy zhurnal [Russian Medical Journal]. 2001; 9 (2): 56. (in Russian)

6. Chernuha G.E. Obesity as a risk factor for disorders of the reproductive system in women. Consilium Medicum. 2007; 9 (6): 115-8. (in Russian)

7. Chernyshova A.L., Kolomiec L.A., Bochkareva N.V., et al. Metabolic syndrome, interraction with endometrial carcinogenesis. Sibirskiy onko-logicheskiy zhurnal [Siberian Oncological Journal]. 2008; 29 (5): 68-74. (in Russian)

8. Ashrafyan L.A., Kiselev V.I. Tumors of the reproductive organs (etiology and pathogenesis). Moscow: Dimitreyd Grafik Grupp, 2007: 216 p. (in Russian)

9. Kiselev V.I., Ashrafyan L.A., Budarina S.O. Kiselev V.I., Ashrafyan L.A., Budarina S.O. The etiological role of human papillomavirus in the development of cervical cancer, genetic and pathogenetic mechanisms, the possibilities of treatment and prevention. Akusherstvo i ginekologiya [Obstetrics and Gynecology]. 2004; 6 (4): 174-9. (in Russian)

10. Jordan V.C. Selective estrogen receptor modulation: concept and consequences in cancer. Cancer Cell. 2004; 5: 2007-13.

11. Hart W.R., Norris H.F. Relation of lihen sclerosus et atrophicus of the vulva to development of carcinoma. Obstet Gynecol. 1975; 45: 369.

12. Djurdjevic S., Segedi D., et al. Modern approach to classification of precancerous conditions and vulvar dystrophy. Med Pregl. 1995; 48 (11-12): 399-404.

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)