Сombination of probiotic and metabiotic in complex treatment of dysbiosis

Normal microbial flora includes all microorganisms that can survive, co-exist and develop in a particular physical medium, and do not cause diseases. Complexity and liveliness of species and quantitative composition of microcenosis provide flexible adaptation of microorganisms to environmental changes. Moreover, vaginal colonization resistance maintain stability of normal microcenosis, prevent vaginal colonization by truly pathogenic microorganisms and overgrowth of opportunistic pathogenic microflora.

The aim of this study was to assess recovery rate of the normal vaginal flora (Lactobacillus titer) using probiotic Provag in capsules for ingestion and metabiotic Provag Gel for external application for restoration of normobiocenosis (as stage II) after treatment of nonspecific vulvovaginitis (NVV).

Combination therapy with probiotic and metabiotic, which may regulate microbial interactions in "bowel-vagina" ecological niche after stage II of treatment increased the Lactobacillus spp. concentration to 5,5x10⁷ He/ml in all 40 patients (relative Lg (N/TBM) was 80-100%). Only 10% had less than -2 Lg (<1%) fraction of facultative anaerobic microorganisms and 30% had less than -2 Lg (<1%) fraction of obligate anaerobic microorganism. Total frequency of facultative obligate anaerobes outflow was minimal [from -2 Lg to -1 Lg (1-10%)]. Pathogenic microorganisms were not identified in any patient. Inclusion of Provag Oral Probiotic in capsules and Provag Gel metabiotic for outward application in package of measures after NVV therapy drive up lactoflora population and lower the degree of colonization up to complete elimination of opportunistic pathogenic bacterium such as staphylococcus, Candida yeasts, streptococcus, enterobacteria, Klebsiella.