Treatment of recurrences of atypical hyperplasia and early endometrial cancer after prior conservative treatment

• Novikova O.V.
• Novikova E.G.
• Volchenko N.N.
• Volchenko N.N.
• Avasova C.A.
• Skreptsova N.S.
• Charkhifalakyan A.V.

Abstract

The aim of this novel study was to evaluate the effectiveness of repeat conservative approach in reproductive age women previously hormonally treated for atypical hyperplasia (AH) and early endometrial cancer (EC). Twenty four patients who were initially diagnosed with AH and 33 with early EC made up for total of 57 patients with recurrences included in this study of whom 45 received hormonal therapy. Complete responses to this treatment were observed in 40 patients (89% total, 89% for AH and 88% for EC groups, not significantly different).

Conclusion. Second hormonal treatment for AH and EC recurrences results in cure in most women allowing them to conceive.

Keywords:atypical endometrial hyperplasia, endometrial cancer, recurrence, fertility

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