The course of pregnancy and labor depending on clinical and laboratory features of systemic lupus erythematosus state

• Klimenchenko N.I.
• Fedorova E.V.
• Kosheleva N.M.

Abstract

Despite significant advances in systemic lupus erythematosus (SLE) treatment in recent years, there are many complex and controversial issues regarding course of pregnancy, labor and neonatal period in women with this disease.

The aim was to study pregnancy, labor and neonatal period courses features in women with SLE depending on disease course clinical variants and immune system state.

Material and methods. Pregnant women clinical and laboratory examination was made and analysis of pregnancy features and its outcomes for mother, fetus and newborn in 93 women was made. All of them were divided into 2 groups: main group - 49 pregnant women with determine a diagnosis of SLE of varying degree of activity; comparison group - 44 pregnant women without severe extragenital or other autoimmune and gynecological pathology.

Results and conclusions. The largest influence on gestation course and labor outcomes make SLE activity rate, its chronicity, prior disease recrudescence in gestation period, anti-phospholipid syndrome (APS)presence; a-Sm-antibodies, La-antibodies levels, C₃ and C₄ complement components levels; conduct therapy. In addition, it is possible to identify prognostically unfavorable factors, such as SLE chronicity, APS presence, C₃- and C₄-complement components reduced levels of and 3-component therapy with cytotoxic drugs usage.

Keywords:pregnancy, labor outcome, systemic lupus erythematosus

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)