Features of a clinical progression of premalignant and vulvar cancer at young people

• O.V. Chulkova
• Novikova E.G.

Abstract

Objectives. Objective of the study was to study vuLva precancer and early cancer clinical progression in women of reproductive age.

Material and methods. From 2011 to 2014 in Р. Hertsen Moscow Oncology Research Institute gynecology department 110 patients with degenerative diseases, vulva precancer and early cancer were examined. The age of the patients included in the study ranged from 18 to 70 years (36±3.5). Two main groups were identified: 1) pre- and postmenopausal (60 women ranged from 49 to 70 years), 2) of reproductive age (50 women ranged from 18 to 49 years).

Results. After vulva biopsy material investigation the authors have found that in group 1 patients with stage IA vulval cancer (27%) predominated compared to VIN (vulvar intraepithelial neoplasia) (13%). In group 2 patients with VIN (28%) predominated compared with invasive neoplastic process (12%). VIN was asymptomatic in more than 50% of cases.

Conclusion. In women of reproductive age vulva neoplasia often detected in VIN form and in all cases is associated with human papillomavirus (HPV) of high oncogenous risk. In women of pre- and postmenopausal age - at the stage of invasive vulvar cancer vulva neoplasia is rarely associated with human papilloma virus (30%). For young patients multifocality is specific, and for patients in pre- and postmenopausal age monofocality is specific.

Keywords:vulvar intraepithelial neoplasia, vulvar cancer, women of reproductive age, human papillomavirus, multifocality, monofocality

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