Comprehensive approach to preventative vitamin therapy of congenital malformations and pregnancy pathology

Numerous recent studies have shown that pathological effects such as cell division disruption, apoptosis and microthrombogenesis occurring before and after implantation increase the level of homocysteine in the blood plasma. Association between between intrauterine pathology and hyperhomocysteinemia has been proven. Spontaneous abortion, intrauterine growth retardation, intrauterine fetal death, placental abruption, preeclampsia, eclampsia, placental insufficiency, disturbance of uteroplacental and fetoplacental circulation, thrombosis and vasculitis, cognitive impairment in children and dementia have a link with hyperhomocysteinemia. Folate deficiency leads to disruption of the synthesis of nucleic acids and proteins, the inhibition of cell division and growth in the fetus, especially the rapidly proliferating tissues such as bone marrow, intestine epithelium. 5-MTHF provides more than 90% of the folate transformations.

Eating disorders woman hypovitaminosis is threatening not only pregnant mother, but congenital polyhypovitaminosis of a newborn. The lag in the development of the fetus occurs when the uterine-placental nutri­tion does not meet the needs of the fetus and the level of essential amino acids is reduced in fetoplacental