Role of genetic polymorphism (HLA-DRB1) in gravidic hypothyroidism development in Russian population
AbstractThe incidence of thyroid disease in pregnant women has been growing lately, reaching 20–25% in some countries. The incidence of hypothyroidism during pregnancy is 10–17%. One of pathogenetic factors of its development is an autoimmune thyroid disease, which is associated with HLA-DR gene polymorphisms development.
Aim. Identify the correlation between genetic polymorphisms of 2nd class human leukocyte antigen HLA-DRB1 with the development of hypothyroidism in pregnant women of russian population.
Material and methods. The study involved 178 women with singleton pregnant women. Study group comprised 65 women with subclinical or symptomatic hypothyroidism. The control group comprised 113 pregnant women without severe extragenital pathology, endocrinopathies, obstetric and gynecological complications. The authors analyzed family history data, determine thyrotropic hormone and free T4 levels, thyroid peroxidase and thyroglobulin antibody levels.
Results. Significant difference between treatment groups was found only in two allele groups: DRB1*04 and DRB1*11. DRB1*04 allelic group is associated with an increased risk of hypothyroidism. The presence of DRB1*11 allele groups is associated with resistance to hypothyroidism.
Conclusion. There was a significant correlation of DRB1*04 allelic groups with development of hypothyroidism in pregnant women, as well as the protective role of DRB1*11 allele groups. That suggests an important role of genetic polymorphisms in the development of thyroid disease.
Keywords:pregnant hypothyroidism autoimmune diseases, major histocompatibility complex genes (HLA), HLADRB1 allele groups, DRB1*11 allele groups, autoimmune hypothyroidism resistance, genetic polymorphism