Uterus transplantation becomes real

Abstract

Before the century of in vitro fertilization the research in reproductive organs transplantation was observed as potential therapy of infertility. Uterus transplantation research has been conducted toward its introduction in the human as a treatment of absolute uterine-factor infertility. Much research on uterus transplantation has been performed in appropriate animal models. Several aspects of the procedure have been optimized but some remain to be solved. It is predicted that the research will soon reach a stage that could merit introduction of human uterus transplantation as an experimental procedure. The indication for uterus transplantation is evident as is its potential to ameliorate the social and personal burdens of these patients. As for the concerns regarding its risk, in perspective it is similar to other high-risk pregnancies. Moving uterus transplantation toward clinical applications obviously will require a continued commitment of research and support. Clinical application of uterus transplantation has just begun, but more basic data are needed and medical, ethical, and social problems require thorough discussion before clinical application.

Keywords:pregnancy, uterine factor infertility, in vitro fertilization, surrogacy, uterus transplantation, Mayer–Rokitansky–Kuster–Hauser syndrome